DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 7960:7968

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9745

ASA_SCORE: 125.8

COIL: 0.5341

CONS_SCORE: 0.2526

DSS_SCORE: 0.6281

HELIX: 0.4488

FCONS_SCORE: 1.0009

RIG_SCORE: 0.8087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I7952M	TCGA-67-3771	LUAD	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.1111
p.G7956R	TCGA-AA-3492	COAD	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.2222
p.G7956R	TCGA-EE-A2GC	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.2222
p.T7967A	TCGA-D3-A8GP	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.7139
p.P7958T	TCGA-D9-A1X3	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.P7958T	SIDM01617	Endometrial Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.P7958T	ACH-000994	Endometrial/Uterine Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.P7971Q	TCGA-ER-A19P	SKCM	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.25
p.H7957Y	TCGA-FI-A2D0	UCEC	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.25
p.H7957Y	DO43891	UCEC	ICGC	KRHNLAQVR	DEG_APCC_DBOX_1	0.25
p.G7968R	TCGA-KU-A66S	HNSC	TCGA	KRHNLAQVR	DEG_APCC_DBOX_1	0.7568
p.G7968R	DO44456	HNSC	ICGC	KRHNLAQVR	DEG_APCC_DBOX_1	0.7568
p.A7950G	SIDM01090	Colorectal Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.0556
p.E7977K	SIDM01174	Cervical Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.0833
p.E7977K	ACH-001402	Cervical Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.0833
p.E7977K	SW756	cervix	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	0.0833
p.A7974V	SIDM00846	Cervical Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.1667
p.A7974V	HeLa	cervix	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	0.1667
p.P7958S	SIDM01228	Melanoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.P7958S	ACH-001024	Skin Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.P7958S	CHL-1	skin	COSMIC	KRHNLAQVR	DEG_APCC_DBOX_1	0.2778
p.G7968A	SIDM01503	Small Cell Lung Carcinoma	GDSC	KRHNLAQVR	DEG_APCC_DBOX_1	0.754
p.G7968A	ACH-000844	Lung Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.754
p.S7966T	ACH-000961	Endometrial/Uterine Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.7116
p.Q7975P	ACH-001645	Skin Cancer	CCLE	KRHNLAQVR	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	7960:7968	KRHNLAQVR	APC,CDC20,FZR1	0.9745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRHNLAQVR

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of KRHNLAQVR