DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: LIG_APCC_ABBA_1

Location: 1026:1031

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6424

ASA_SCORE: 69.8833

COIL: 0.3137

CONS_SCORE: 0.4425

DSS_SCORE: 0.2889

HELIX: 0.0182

FCONS_SCORE: 0.8301

RIG_SCORE: 0.815

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1038K	TCGA-2F-A9KT	BLCA	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.R1038K	DO52599	BOCA	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.C1035R	TCGA-A5-A0GP	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.2222
p.R1038S	TCGA-AG-3891	READ	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.T1036M	TCGA-AX-A063	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.1944
p.T1036M	SIDM02035	Colorectal Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.1944
p.R1037H	TCGA-B5-A3FC	UCEC	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.1667
p.C1029Y	TCGA-XK-AAIW	PRAD	TCGA	LKVHVE	LIG_APCC_ABBA_1	0.7087
p.A1032V	DO8264	COAD	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.3056
p.A1032S	DO229029	LICA	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.3056
p.V1030L	DO229008	LICA	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.5654
p.V1041L	DO24920	LUAD	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.0556
p.L1022P	DO28731	OV	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.2222
p.R1036G	DO229234	THCA	ICGC	LKVHVE	LIG_APCC_ABBA_1	0.1944
p.A1032P	SIDM00422	Hodgkin's Lymphoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.3056
p.A1032P	ACH-001203	Lymphoma	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.3056
p.A1032P	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.3056
p.R1038M	SIDM00789	Colorectal Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.R1038M	ACH-001061	Colon/Colorectal Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.R1038M	HCT-15	large_intestine	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.1389
p.C1029F	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.7108
p.C1029F	ACH-000647	Esophageal Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.7108
p.C1029F	TE-1	oesophagus	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.7108
p.M1030V	SIDM00231	Kidney Carcinoma	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.7208
p.M1030V	ACH-002167	Kidney Cancer	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.7208
p.M1030V	NCC010	kidney	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.7208
p.E1031G	SIDM01424	B-Lymphoblastic Leukemia	GDSC	LKVHVE	LIG_APCC_ABBA_1	0.7199
p.E1031G	ACH-000782	Leukemia	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.7199
p.E1031G	ACH-001735	Leukemia	CCLE	LKVHVE	LIG_APCC_ABBA_1	0.7199
p.R1037Q	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.1667
p.D1018G	Caov-4	ovary	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.1111
p.R1037C	RL95-2	endometrium	COSMIC	LKVHVE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKVHVE

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of LKVHVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	LIG_APCC_ABBA_1	1026:1031	LKVHVE	APC,CDC20,FZR1	0.6424	More...