DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 3645:3653

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.716

ASA_SCORE: 60

COIL: 0.4421

CONS_SCORE: 0.4929

DSS_SCORE: 0.2721

HELIX: 0.0042

FCONS_SCORE: 0.923

RIG_SCORE: 0.8343

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3646W	HUH-6-clone5	liver	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.8634
p.V3652I	TCGA-D1-A17Q	UCEC	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.V3652I	DO41903	UCEC	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.V3652I	SIDM02015	Colorectal Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.A3642V	TCGA-06-5416	GBM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	TCGA-AA-A010	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	TCGA-AF-2693	READ	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO48282	ESCA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO10880	GBM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO36766	READ	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642G	ACH-001024	Skin Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3653G	IGROV-1	ovary	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.6429
p.V3644L	DO228916	LICA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	SIDM00373	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	ACH-000974	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	ACH-002026	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	SNG-M	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.P3655L	TCGA-EB-A24D	SKCM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.P3655L	DO37440	SKCM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.P3643A	ACH-001853	Bile Duct Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.V3655L	NCI-H441	lung	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.S3660I	SIDM01088	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.S3660I	ACH-000965	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.S3660I	RL95-2	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.R3662C	TCGA-AA-3815	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with OBSCN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRCELSKMA

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	3645:3653	LRCELSKMA	APC,CDC20,FZR1	0.716	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRCELSKMA

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of LRCELSKMA