DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 3645:3653

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.716

ASA_SCORE: 60

COIL: 0.4421

CONS_SCORE: 0.4929

DSS_SCORE: 0.2721

HELIX: 0.0042

FCONS_SCORE: 0.923

RIG_SCORE: 0.8343

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3642V	TCGA-06-5416	GBM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	TCGA-AA-A010	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	TCGA-AF-2693	READ	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO48282	ESCA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO10880	GBM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.A3642V	DO36766	READ	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.R3662C	TCGA-AA-3815	COAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662C	TCGA-B5-A11J	UCEC	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662C	TCGA-M8-A5N4	PAAD	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662C	DO9924	COAD	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662C	DO50264	PAAD	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662C	DO43698	UCEC	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.V3652I	TCGA-D1-A17Q	UCEC	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.V3652I	DO41903	UCEC	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.V3652I	SIDM02015	Colorectal Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.7076
p.P3655L	TCGA-EB-A24D	SKCM	TCGA	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.P3655L	DO37440	SKCM	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.V3644L	DO228916	LICA	ICGC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	SIDM00373	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	ACH-000974	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	ACH-002026	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.V3644M	SNG-M	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.3056
p.S3660I	SIDM01088	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.S3660I	ACH-000965	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.S3660I	RL95-2	endometrium	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.1389
p.R3662P	SIDM00837	Colorectal Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662P	ACH-000958	Colon/Colorectal Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662P	SW48	large_intestine	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662H	SIDM01617	Endometrial Carcinoma	GDSC	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.R3662H	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.0833
p.A3642G	ACH-001024	Skin Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.6944
p.P3643A	ACH-001853	Bile Duct Cancer	CCLE	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.A3653G	IGROV-1	ovary	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.6429
p.V3655L	NCI-H441	lung	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.2778
p.R3646W	HUH-6-clone5	liver	COSMIC	LRCELSKMA	DEG_APCC_DBOX_1	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRCELSKMA

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of LRCELSKMA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	3645:3653	LRCELSKMA	APC,CDC20,FZR1	0.716	More...