DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 3204:3212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8

ASA_SCORE: 52.2

COIL: 0.4217

CONS_SCORE: 0.5804

DSS_SCORE: 0.0472

HELIX: 0.0053

FCONS_SCORE: 1.3348

RIG_SCORE: 0.8745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3196Q	TCGA-EE-A29E	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.P3196Q	DO37831	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.D3195N	TCGA-FW-A3R5	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	0.0833
p.D3195N	DO37406	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.0833
p.P3196S	TCGA-GN-A8LK	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.P3196S	DO51259	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.P3196L	TCGA-GN-A8LK	SKCM	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.P3196L	DO51259	SKCM	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.1111
p.Q3213H	TCGA-OR-A5KB	ACC	TCGA	LRCVLSSVA	DEG_APCC_DBOX_1	0.3056
p.R3211C	DO225226	BRCA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.8301
p.R3211C	DO233888	GACA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.8301
p.S3208T	DO225448	GACA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.7116
p.A3197S	DO229027	LICA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.1389
p.G3202S	DO232761	PBCA	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.2778
p.G3202S	ACH-001377	Pancreatic Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	0.2778
p.R3216C	DO43763	UCEC	ICGC	LRCVLSSVA	DEG_APCC_DBOX_1	0.3333
p.R3216C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRCVLSSVA	DEG_APCC_DBOX_1	0.3333
p.R3216C	ACH-000937	Leukemia	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	0.3333
p.R3216C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	0.3333
p.S3210N	SIDM00150	Colorectal Carcinoma	GDSC	LRCVLSSVA	DEG_APCC_DBOX_1	0.5958
p.S3210N	ACH-000969	Colon/Colorectal Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	0.5958
p.S3210N	KM12	large_intestine	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	0.5958
p.S3208G	ACH-001610	Brain Cancer	CCLE	LRCVLSSVA	DEG_APCC_DBOX_1	0.6993
p.V3215M	SNG-M	endometrium	COSMIC	LRCVLSSVA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	3204:3212	LRCVLSSVA	APC,CDC20,FZR1	0.8	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRCVLSSVA

Degron related mutations and impact score

Drug responses associated with OBSCN mutations

All proteins holding degron of LRCVLSSVA