DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: DEG_APCC_DBOX_1

Location: 713:721

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6946

ASA_SCORE: 85.0667

COIL: 0.3873

CONS_SCORE: 0.5159

DSS_SCORE: 0.3333

HELIX: 0.01

FCONS_SCORE: 1.0827

RIG_SCORE: 0.8121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A728V	TCGA-AX-A2HJ	UCEC	TCGA	AREVLARLH	DEG_APCC_DBOX_1	0.1389
p.A728V	DO42105	UCEC	ICGC	AREVLARLH	DEG_APCC_DBOX_1	0.1389
p.E729K	TCGA-VS-A94Z	CESC	TCGA	AREVLARLH	DEG_APCC_DBOX_1	0.1111
p.E729K	DO51634	CESC	ICGC	AREVLARLH	DEG_APCC_DBOX_1	0.1111
p.A728T	DO233219	GACA	ICGC	AREVLARLH	DEG_APCC_DBOX_1	0.1389
p.E729A	DO232445	PBCA	ICGC	AREVLARLH	DEG_APCC_DBOX_1	0.1111
p.E729A	ACH-001329	Brain Cancer	CCLE	AREVLARLH	DEG_APCC_DBOX_1	0.1111
p.E722K	SIDM00854	Burkitt's Lymphoma	GDSC	AREVLARLH	DEG_APCC_DBOX_1	0.3056
p.A711T	ACH-001031	Rhabdoid	CCLE	AREVLARLH	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	DEG_APCC_DBOX_1	713:721	AREVLARLH	APC,CDC20,FZR1	0.6946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons