DegronMD

Uniprot ID: Q5VST9

Source protein: Obscurin

Source gene: OBSCN

Class: LIG_APCC_ABBA_1

Location: 2033:2038

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6572

ASA_SCORE: 52.35

COIL: 0.0573

CONS_SCORE: 0.576

DSS_SCORE: 0.3387

HELIX: 0.0058

FCONS_SCORE: 1.1436

RIG_SCORE: 0.7859

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W2034R	SIDM01608	Endometrial Carcinoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.8634
p.Y2035F	SIDM00845	Burkitt's Lymphoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.7528
p.Y2035F	SIDM00461	Acute Myeloid Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.7528
p.Y2035F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.7528
p.Y2035F	SIDM01519	Head and Neck Carcinoma	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.7528
p.E2038K	SW756	cervix	COSMIC	VEIHAE	LIG_APCC_ABBA_1	0.7022
p.V2032M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VEIHAE	LIG_APCC_ABBA_1	0.3056
p.V2032M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VEIHAE	LIG_APCC_ABBA_1	0.3056
p.G2039C	ACH-000920	Leukemia	CCLE	VEIHAE	LIG_APCC_ABBA_1	0.3056
p.M2030I	DO229056	LICA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.25
p.R2041P	647-V	urinary_tract	COSMIC	VEIHAE	LIG_APCC_ABBA_1	0.25
p.V2045A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VEIHAE	LIG_APCC_ABBA_1	0.1389
p.H2048R	DO229010	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO229013	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO229016	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO229003	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO229005	COCA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO229047	LICA	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556
p.H2048R	DO230937	LUSC	ICGC	VEIHAE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VST9	Obscurin	LIG_APCC_ABBA_1	2033:2038	VEIHAE	APC,CDC20,FZR1	0.6572	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons