DegronMD - Q8N5Q1(GARIN5B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M860I	TCGA-AX-A1CE	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.0833
p.M860I	DO42280	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.0833
p.L152F	TCGA-B0-5699	KIRC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.0833
p.L152F	DO16486	KIRC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.0833
p.A171T	TCGA-B5-A3FC	UCEC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A171T	DO233205	GACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A171T	DO41871	UCEC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.L876I	TCGA-CA-6718	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.L876I	TCGA-QS-A5YQ	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.L876I	DO7801	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.L876I	DO49073	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.S377Y	TCGA-DD-A73G	LIHC	TCGA	LSTPYSS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.712
p.S377Y	DO48473	LIHC	ICGC	LSTPYSS	DEG_SCF_FBW7_1	371:377	Mutation altering degron motif	0.712
p.T868I	TCGA-EK-A2IP	CESC	TCGA	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.3056
p.T868I	DO48978	CESC	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.3056
p.A171G	TCGA-EK-A2R7	CESC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A171G	DO49943	CESC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.R5Q	TCGA-EO-A22U	UCEC	TCGA	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.3056
p.R5Q	DO43755	UCEC	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.3056
p.V495I	TCGA-EY-A1GF	UCEC	TCGA	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2222
p.V495I	DO41704	UCEC	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2222
p.L876R	TCGA-JU-AAVI	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.L876R	DO219776	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.25
p.A171P	DO222946	BTCA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.A171P	ACH-000967	Colon/Colorectal Cancer	CCLE	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.25
p.R151C	DO229010	COCA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.0556
p.W19L	DO234269	ESAD	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1944
p.A494V	DO233270	GACA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.L13H	DO228278	LICA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.7313
p.P865H	DO228916	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.2222
p.P176T	DO229025	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1111
p.L173M	DO229027	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1944
p.T168K	DO229026	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.7306
p.N6K	DO229034	LICA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.5806
p.T167I	DO220862	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.5966
p.P489S	DO220902	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.P489L	DO220902	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.P489L	DO37432	SKCM	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.P17S	DO220906	MELA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.P498S	DO222632	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.3056
p.S873L	DO222683	MELA	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation altering degron motif	0.7667
p.P161S	DO222753	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation altering degron motif	0.6752
p.P159S	DO222702	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.2778
p.M175T	DO232849	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1389
p.P176S	DO232858	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.1111
p.A178S	DO233293	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.0556
p.A385T	DO51515	PACA	ICGC	LSTPYSS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.1111
p.L880F	DO35442	PACA	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.1389
p.G351R	DO231284	PACA	ICGC	DSGGST	DEG_SCF_TRCP1_1	349:354	Mutation altering degron motif	0.7568
p.T868P	DO219877	SKCA	ICGC	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.3056
p.A497T	DO229275	THCA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.P367L	DO231308	THCA	ICGC	LSTPYSS	DEG_SCF_FBW7_1	371:377	Mutation rewiring degron network	0.2222
p.S356L	ACH-000670	Lung Cancer	CCLE	DSGGST	DEG_SCF_TRCP1_1	349:354	Mutation rewiring degron network	0.2778
p.P17L	ACH-000720	Bladder Cancer	CCLE	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.P17L	TCCSUP	urinary tract	COSMIC	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.G351V	ACH-000803	Lung Cancer	CCLE	DSGGST	DEG_SCF_TRCP1_1	349:354	Mutation altering degron motif	0.7532
p.A862S	ACH-000921	Lung Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.1389
p.R169C	ACH-000947	Ovarian Cancer	CCLE	PTWTPRTT	DEG_SCF_FBW7_1	161:168	Mutation rewiring degron network	0.3056
p.E882D	ACH-001852	Bile Duct Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	869:873	Mutation rewiring degron network	0.0833
p.C9Y	ACH-002026	Endometrial/Uterine Cancer	CCLE	NRRCLEPLQ	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.5976

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GARIN5B

UniProt ID: Q8N5Q1

Entrez ID: 284418

Protein name: Golgi associated RAB2 interactor protein 5B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GARIN5B in