DegronMD

Uniprot ID: Q8N5Q1

Source protein: Golgi associated RAB2 interactor protein 5B

Source gene: GARIN5B

Class: DEG_SCF_FBW7_1

Location: 371:377

E3 ligase: FBXW7

DEGRON score: 0.9116

ASA_SCORE: 85.9286

COIL: 0.9567

CONS_SCORE: 0.5037

DSS_SCORE: 0.539

HELIX: 0.0206

FCONS_SCORE: 0.9944

RIG_SCORE: 0.6872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S377Y	TCGA-DD-A73G	LIHC	TCGA	LSTPYSS	DEG_SCF_FBW7_1	0.712
p.S377Y	DO48473	LIHC	ICGC	LSTPYSS	DEG_SCF_FBW7_1	0.712
p.A385T	DO51515	PACA	ICGC	LSTPYSS	DEG_SCF_FBW7_1	0.1111
p.P367L	DO231308	THCA	ICGC	LSTPYSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SCF_FBW7_1	371:377	LSTPYSS	FBXW7	0.9116	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons