DegronMD

Uniprot ID: Q8N5Q1

Source protein: Golgi associated RAB2 interactor protein 5B

Source gene: GARIN5B

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8568

ASA_SCORE: 110.2778

COIL: 0.9129

CONS_SCORE: 0.3045

DSS_SCORE: 0.2439

HELIX: 0.0549

FCONS_SCORE: 0.7566

RIG_SCORE: 0.8064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5Q	TCGA-EO-A22U	UCEC	TCGA	NRRCLEPLQ	DEG_APCC_DBOX_1	0.3056
p.R5Q	DO43755	UCEC	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.3056
p.W19L	DO234269	ESAD	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.1944
p.L13H	DO228278	LICA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.7313
p.N6K	DO229034	LICA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.5806
p.P17S	DO220906	MELA	ICGC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.25
p.P17L	ACH-000720	Bladder Cancer	CCLE	NRRCLEPLQ	DEG_APCC_DBOX_1	0.25
p.P17L	TCCSUP	urinary_tract	COSMIC	NRRCLEPLQ	DEG_APCC_DBOX_1	0.25
p.C9Y	ACH-002026	Endometrial/Uterine Cancer	CCLE	NRRCLEPLQ	DEG_APCC_DBOX_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_APCC_DBOX_1	6:14	NRRCLEPLQ	APC,CDC20,FZR1	0.8568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons