DegronMD

Uniprot ID: Q8N5Q1

Source protein: Golgi associated RAB2 interactor protein 5B

Source gene: GARIN5B

Class: DEG_SCF_FBW7_1

Location: 161:168

E3 ligase: FBXW7

DEGRON score: 0.7189

ASA_SCORE: 79.1125

COIL: 0.8699

CONS_SCORE: 0.5032

DSS_SCORE: 0.4633

HELIX: 0.0859

FCONS_SCORE: 0.859

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L152F	TCGA-B0-5699	KIRC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	0.0833
p.L152F	DO16486	KIRC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.0833
p.A171T	TCGA-B5-A3FC	UCEC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171T	DO233205	GACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171T	DO41871	UCEC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171G	TCGA-EK-A2R7	CESC	TCGA	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171G	DO49943	CESC	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171P	DO222946	BTCA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.A171P	ACH-000967	Colon/Colorectal Cancer	CCLE	PTWTPRTT	DEG_SCF_FBW7_1	0.25
p.R151C	DO229010	COCA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.0556
p.P176T	DO229025	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.1111
p.L173M	DO229027	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.1944
p.T168K	DO229026	LICA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.7306
p.T167I	DO220862	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.5966
p.P161S	DO222753	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.6752
p.P159S	DO222702	MELA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.2778
p.M175T	DO232849	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.1389
p.P176S	DO232858	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.1111
p.A178S	DO233293	NACA	ICGC	PTWTPRTT	DEG_SCF_FBW7_1	0.0556
p.R169C	ACH-000947	Ovarian Cancer	CCLE	PTWTPRTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SCF_FBW7_1	161:168	PTWTPRTT	FBXW7	0.7189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons