DegronMD

Uniprot ID: Q8N5Q1

Source protein: Golgi associated RAB2 interactor protein 5B

Source gene: GARIN5B

Class: DEG_SCF_FBW7_1

Location: 499:506

E3 ligase: FBXW7

DEGRON score: 0.99

ASA_SCORE: 104.975

COIL: 0.9599

CONS_SCORE: 0.5449

DSS_SCORE: 0.7577

HELIX: 0.0225

FCONS_SCORE: 1.0547

RIG_SCORE: 0.4992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V495I	TCGA-EY-A1GF	UCEC	TCGA	PQKTPPPS	DEG_SCF_FBW7_1	0.2222
p.V495I	DO41704	UCEC	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.2222
p.A494V	DO233270	GACA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.1944
p.P489S	DO220902	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.0556
p.P489L	DO220902	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.0556
p.P489L	DO37432	SKCM	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.0556
p.P498S	DO222632	MELA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.3056
p.A497T	DO229275	THCA	ICGC	PQKTPPPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SCF_FBW7_1	499:506	PQKTPPPS	FBXW7	0.99	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons