DegronMD - Q5SXH7(PLEKHS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D177N	TCGA-17-Z061	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.A165V	TCGA-18-3409	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.A165V	TCGA-18-3409	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.A165V	DO26444	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.A165V	DO26444	LUSC	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.V203M	TCGA-50-5933	LUAD	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0833
p.L210V	TCGA-58-A46K	LUSC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.R172I	TCGA-AX-A2HC	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.R172I	TCGA-AX-A2HC	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.R172I	TCGA-EI-6917	READ	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.R172I	TCGA-EI-6917	READ	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.R172I	TCGA-ND-A4WC	UCS	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.R172I	TCGA-ND-A4WC	UCS	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.R172I	DO36881	READ	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.R172I	DO36881	READ	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.R172I	DO41572	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.R172I	DO41572	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.L216I	TCGA-BK-A6W3	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7174
p.Q176R	TCGA-BS-A0UV	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.D202Y	TCGA-D1-A103	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0556
p.H208P	TCGA-DA-A1IB	SKCM	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.R213Q	TCGA-DF-A2KV	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	TCGA-F5-6814	READ	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	TCGA-GS-A9TZ	DLBC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	SIDM00193	Colorectal Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	ACH-000991	Colon/Colorectal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R213Q	SNU-81	large intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.S154G	TCGA-DU-6392	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.6389
p.S154G	DO22237	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.6389
p.H208Y	TCGA-EE-A2MR	SKCM	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.L156V	TCGA-GU-AATO	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.L156V	TCGA-GU-AATO	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.L156V	DO51893	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.25
p.L156V	DO51893	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.F151Y	TCGA-RY-A83Z	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1111
p.S225F	TCGA-WE-AAA0	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation altering degron motif	0.7982
p.H214D	DO222867	BTCA	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7688
p.V166I	DO6922	CLLE	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7076
p.F157I	DO229010	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.F157I	DO229010	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.F157I	DO234285	ESAD	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.F157I	DO234285	ESAD	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.F157I	DO225404	LAML	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.F157I	DO225404	LAML	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.R219Q	DO219918	DLBC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R219Q	DO36556	READ	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R219Q	DO219771	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.R219Q	SNU-81	large intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7329
p.F157Y	DO219839	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.F157Y	DO219839	LGG	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.G164V	DO228986	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.3056
p.G164V	DO228986	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.A230S	DO229028	LICA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation altering degron motif	0.7588
p.A230S	DO229026	LICA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation altering degron motif	0.7588
p.C165F	DO229022	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2778
p.C165F	DO229022	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.H155R	DO25797	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.V209M	DO24800	LUAD	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation blocking phosphorylation signal	0.6944
p.L216V	DO45432	LUSC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.6765
p.L150F	DO220903	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0833
p.H214Y	DO37819	SKCM	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7229
p.H155N	DO37715	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.H214P	DO38033	SKCM	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.7694
p.S231F	DO51294	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.3056
p.L222I	DO50076	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2778
p.L222I	DO50076	UCEC	ICGC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.25
p.D208Y	DO42312	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.D220N	SIDM00129	Melanoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5821
p.D220N	ACH-002121	Skin Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5821
p.D220N	G-MEL	skin	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.5821
p.R213L	SIDM00971	Breast Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8428
p.R213L	ACH-000828	Breast Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8428
p.R213L	ZR-75-30	breast	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8428
p.G236A	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.1667
p.G236A	ACH-002264	Esophageal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.1667
p.G236A	KYSE-50	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.1667
p.I223S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.I223S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.2778
p.I223S	ACH-000784	Esophageal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.I223S	ACH-000784	Esophageal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.2778
p.I223S	KYSE-70	oesophagus	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.25
p.I223S	KYSE-70	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.2778
p.E218K	SIDM00527	Colorectal Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.591
p.E218K	ACH-000935	Colon/Colorectal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.591
p.E218K	MDST8	large intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.591
p.E237G	SNG-M	endometrium	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.1389
p.R219L	ZR-75-30	breast	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation altering degron motif	0.8428
p.S207P	HCT-15	large intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.1944
p.I229S	KYSE-70	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation altering degron motif	0.7341
p.D226N	G-MEL	skin	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation altering degron motif	0.6932
p.E153G	SNG-M	endometrium	COSMIC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.D232N	HCC-33	lung	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.2778
p.L159F	KYSE-220	oesophagus	COSMIC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6981
p.L202M	NCI-H1792	lung	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.0556
p.R176Q	CTB-1	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1667
p.E224K	MDST8	large intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	212:220	Mutation rewiring degron network	0.2222
p.E224K	MDST8	large intestine	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	225:230	Mutation rewiring degron network	0.3056
p.G154A	KYSE-50	oesophagus	COSMIC	PSSTS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHS1

UniProt ID: Q5SXH7

Entrez ID: 79949

Protein name: Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHS1 in