DegronMD

Uniprot ID: Q5SXH7

Source protein: Pleckstrin homology domain-containing family S member 1

Source gene: PLEKHS1

Class: DEG_APCC_DBOX_1

Location: 212:220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7222

ASA_SCORE: 85.3222

COIL: 0.6404

CONS_SCORE: 0.4541

DSS_SCORE: 0.3657

HELIX: 0.2892

FCONS_SCORE: 1.0623

RIG_SCORE: 0.8339

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V203M	TCGA-50-5933	LUAD	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.0833
p.L210V	TCGA-58-A46K	LUSC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.2778
p.L216I	TCGA-BK-A6W3	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.7174
p.D202Y	TCGA-D1-A103	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.0556
p.H208P	TCGA-DA-A1IB	SKCM	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.2222
p.R213Q	TCGA-DF-A2KV	UCEC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R213Q	TCGA-F5-6814	READ	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R213Q	TCGA-GS-A9TZ	DLBC	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R213Q	SIDM00193	Colorectal Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R213Q	ACH-000991	Colon/Colorectal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R213Q	SNU-81	large_intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.H208Y	TCGA-EE-A2MR	SKCM	TCGA	PRSVLLELD	DEG_APCC_DBOX_1	0.2222
p.H214D	DO222867	BTCA	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7688
p.R219Q	DO219918	DLBC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R219Q	DO36556	READ	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R219Q	DO219771	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.R219Q	SNU-81	large_intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.7329
p.V209M	DO24800	LUAD	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.6944
p.L216V	DO45432	LUSC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.6765
p.H214Y	DO37819	SKCM	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7229
p.H214P	DO38033	SKCM	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.7694
p.L222I	DO50076	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.2778
p.D208Y	DO42312	UCEC	ICGC	PRSVLLELD	DEG_APCC_DBOX_1	0.2222
p.D220N	SIDM00129	Melanoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	0.5821
p.D220N	ACH-002121	Skin Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	0.5821
p.D220N	G-MEL	skin	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.5821
p.R213L	SIDM00971	Breast Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	0.8428
p.R213L	ACH-000828	Breast Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	0.8428
p.R213L	ZR-75-30	breast	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.8428
p.I223S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	0.25
p.I223S	ACH-000784	Esophageal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	0.25
p.I223S	KYSE-70	oesophagus	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.25
p.E218K	SIDM00527	Colorectal Carcinoma	GDSC	PRSVLLELD	DEG_APCC_DBOX_1	0.591
p.E218K	ACH-000935	Colon/Colorectal Cancer	CCLE	PRSVLLELD	DEG_APCC_DBOX_1	0.591
p.E218K	MDST8	large_intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.591
p.R219L	ZR-75-30	breast	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.8428
p.S207P	HCT-15	large_intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.1944
p.L202M	NCI-H1792	lung	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.0556
p.E224K	MDST8	large_intestine	COSMIC	PRSVLLELD	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSVLLELD

Degron related mutations and impact score

Drug responses associated with PLEKHS1 mutations

All proteins holding degron of PRSVLLELD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_APCC_DBOX_1	212:220	PRSVLLELD	APC,CDC20,FZR1	0.7222	More...