DegronMD

Uniprot ID: Q5SXH7

Source protein: Pleckstrin homology domain-containing family S member 1

Source gene: PLEKHS1

Class: DEG_Kelch_Keap1_1

Location: 225:230

E3 ligase: KEAP1

DEGRON score: 0.8703

ASA_SCORE: 87.8667

COIL: 0.9245

CONS_SCORE: 0.4405

DSS_SCORE: 0.5604

HELIX: 0.054

FCONS_SCORE: 0.9761

RIG_SCORE: 0.6367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S225F	TCGA-WE-AAA0	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.7982
p.A230S	DO229028	LICA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.7588
p.A230S	DO229026	LICA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.7588
p.S231F	DO51294	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.3056
p.L222I	DO50076	UCEC	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.25
p.G236A	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	0.1667
p.G236A	ACH-002264	Esophageal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	0.1667
p.G236A	KYSE-50	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.1667
p.I223S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	0.2778
p.I223S	ACH-000784	Esophageal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	0.2778
p.I223S	KYSE-70	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.2778
p.E237G	SNG-M	endometrium	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.1389
p.I229S	KYSE-70	oesophagus	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.7341
p.D226N	G-MEL	skin	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.6932
p.D232N	HCC-33	lung	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.2778
p.E224K	MDST8	large_intestine	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_Kelch_Keap1_1	225:230	SSDSGE	KEAP1	0.8703	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_Kelch_Keap1_1	248:253	SSDSGE	KEAP1	0.9981	More...
O14513	Nck-associated protein 5	DEG_Kelch_Keap1_1	903:908	SSDSGE	KEAP1	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons