DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
SSDSGE
Uniprot ID:
Q8N350
Source protein:
Voltage-dependent calcium channel beta subunit-associated regulatory protein
Source gene:
CBARP
Class:
DEG_Kelch_Keap1_1
Location:
248:253
E3 ligase:
KEAP1
DEGRON score:
0.9981
ASA_SCORE:
79.2667
COIL:
0.9177
CONS_SCORE:
0.435
DSS_SCORE:
0.6476
HELIX:
0.0463
FCONS_SCORE:
1.2585
RIG_SCORE:
0.556
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CBARP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SSDSGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5SXH7
Pleckstrin homology domain-containing family S member 1
DEG_Kelch_Keap1_1
225:230
SSDSGE
KEAP1
0.8703
More...
Q8N350
Voltage-dependent calcium channel beta subunit-associated regulatory protein
DEG_Kelch_Keap1_1
248:253
SSDSGE
KEAP1
0.9981
More...
O14513
Nck-associated protein 5
DEG_Kelch_Keap1_1
903:908
SSDSGE
KEAP1
0.9887
More...