DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_Kelch_Keap1_1

Location: 903:908

E3 ligase: KEAP1

DEGRON score: 0.9887

ASA_SCORE: 91.6333

COIL: 0.9568

CONS_SCORE: 0.6666

DSS_SCORE: 0.8276

HELIX: 0.0192

FCONS_SCORE: 2.0954

RIG_SCORE: 0.4792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S895L	TCGA-12-0616	GBM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.1111
p.S895L	DO12718	GBM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.1111
p.D905N	TCGA-55-7726	LUAD	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.6932
p.D905N	DO25594	LUAD	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.6932
p.A900V	TCGA-AZ-4614	COAD	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.25
p.A900V	DO10012	COAD	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.25
p.A900V	DO228581	GACA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.25
p.G894V	TCGA-D3-A3CE	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.0833
p.G894V	DO37405	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.0833
p.E902K	TCGA-FW-A3R5	SKCM	TCGA	SSDSGE	DEG_Kelch_Keap1_1	0.3056
p.E902K	DO37406	SKCM	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.3056
p.S918Y	DO233811	GACA	ICGC	SSDSGE	DEG_Kelch_Keap1_1	0.0556
p.H915Y	SIDM00565	Oral Cavity Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	0.1389
p.H915Y	ACH-001626	Head and Neck Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	0.1389
p.H915Y	OSC-20	upper_aerodigestive_tract	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.1389
p.S895P	SIDM00680	Colorectal Carcinoma	GDSC	SSDSGE	DEG_Kelch_Keap1_1	0.1111
p.S895P	ACH-000957	Colon/Colorectal Cancer	CCLE	SSDSGE	DEG_Kelch_Keap1_1	0.1111
p.S895P	LS-180	large_intestine	COSMIC	SSDSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_Kelch_Keap1_1	225:230	SSDSGE	KEAP1	0.8703	More...
Q8N350	Voltage-dependent calcium channel beta subunit-associated regulatory protein	DEG_Kelch_Keap1_1	248:253	SSDSGE	KEAP1	0.9981	More...
O14513	Nck-associated protein 5	DEG_Kelch_Keap1_1	903:908	SSDSGE	KEAP1	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons