DegronMD - Q6IMN6(CAPRIN2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V599L	TCGA-38-4626	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2222
p.V599L	DO24447	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2222
p.P598S	TCGA-A5-A0G2	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.P598S	DO41235	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.P759S	TCGA-AB-2828	LAML	TCGA	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1111
p.T955A	TCGA-AX-A1CE	UCEC	TCGA	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.1667
p.Q743E	TCGA-CR-7376	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.2222
p.D594Y	TCGA-D1-A17Q	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0833
p.D594Y	DO41903	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0833
p.N974H	TCGA-DB-5270	LGG	TCGA	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.1389
p.N974H	DO22745	LGG	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.1389
p.S607F	TCGA-UU-A93S	BRCA	TCGA	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7982
p.S607F	DO219645	BRCA	ICGC	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7982
p.L609V	TCGA-ZN-A9VU	MESO	TCGA	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.G960C	DO484	BLCA	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.3056
p.Q757E	DO15455	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.S607Y	DO229032	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.712
p.P739T	DO229037	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation blocking phosphorylation signal	0.5556
p.P753H	DO229045	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.2778
p.L971I	DO46606	OV	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.2222
p.P972L	DO37839	SKCM	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.1944
p.R741Q	DO47769	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.R741Q	DO43186	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.R741Q	DO41903	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.R741Q	DO41331	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.P737H	DO48172	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation substituting flanking lysine	0.1667
p.R741L	DO43041	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1667
p.S744G	SIDM00099	Mesothelioma	GDSC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.25
p.S744G	H2722	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.25
p.G977E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.G977E	ACH-000823	Esophageal Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.G977E	KYSE-140	oesophagus	COSMIC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.G977R	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.G977R	ACH-000823	Esophageal Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.G977R	KYSE-140	oesophagus	COSMIC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation rewiring degron network	0.0556
p.P966H	SIDM01622	Breast Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation altering degron motif	0.7694
p.P966H	ACH-000721	Breast Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation altering degron motif	0.7694
p.T962A	SIDM01442	Glioma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation altering degron motif	0.7139
p.T962A	ACH-000807	Brain Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	961:967	Mutation altering degron motif	0.7139
p.P737L	ACH-000280	Ovarian Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	747:751	Mutation substituting flanking lysine	0.1667
p.S758G	ACH-002128	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1389
p.S758G	H2722	pleura	COSMIC	PASSS	DEG_SPOP_SBC_1	747:751	Mutation rewiring degron network	0.1389

Kaplan plot for CAPRIN2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAPRIN2

UniProt ID: Q6IMN6

Entrez ID: 65981

Protein name: Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CAPRIN2 in