DegronMD

Uniprot ID: Q6IMN6

Source protein: Caprin-2

Source gene: CAPRIN2

Class: DEG_SCF_TRCP1_1

Location: 961:967

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 64.4286

COIL: 0.7826

CONS_SCORE: 0.4989

DSS_SCORE: 0.7064

HELIX: 0.0797

FCONS_SCORE: 1.2958

RIG_SCORE: 0.536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T955A	TCGA-AX-A1CE	UCEC	TCGA	DSGQGDS	DEG_SCF_TRCP1_1	0.1667
p.N974H	TCGA-DB-5270	LGG	TCGA	DSGQGDS	DEG_SCF_TRCP1_1	0.1389
p.N974H	DO22745	LGG	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	0.1389
p.G960C	DO484	BLCA	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	0.3056
p.L971I	DO46606	OV	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	0.2222
p.P972L	DO37839	SKCM	ICGC	DSGQGDS	DEG_SCF_TRCP1_1	0.1944
p.G977E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.G977E	ACH-000823	Esophageal Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.G977E	KYSE-140	oesophagus	COSMIC	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.G977R	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.G977R	ACH-000823	Esophageal Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.G977R	KYSE-140	oesophagus	COSMIC	DSGQGDS	DEG_SCF_TRCP1_1	0.0556
p.P966H	SIDM01622	Breast Carcinoma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	0.7694
p.P966H	ACH-000721	Breast Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	0.7694
p.T962A	SIDM01442	Glioma	GDSC	DSGQGDS	DEG_SCF_TRCP1_1	0.7139
p.T962A	ACH-000807	Brain Cancer	CCLE	DSGQGDS	DEG_SCF_TRCP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IMN6	Caprin-2	DEG_SCF_TRCP1_1	961:967	DSGQGDS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons