DegronMD

Uniprot ID: Q9H5N1

Source protein: Rab GTPase-binding effector protein 2

Source gene: RABEP2

Class: ITCH

Location: 281:284

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8333

ASA_SCORE: 86.55

COIL: 0.9098

CONS_SCORE: 0.4042

DSS_SCORE: 0.4993

HELIX: 0.049

FCONS_SCORE: 0.9679

RIG_SCORE: 0.7015

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P282A	SIDM00622	Glioblastoma	GDSC	PPGY	ITCH	0.7503
p.P282A	ACH-002224	Brain Cancer	CCLE	PPGY	ITCH	0.7503
p.P282A	D-247MG	central_nervous_system	COSMIC	PPGY	ITCH	0.7503
p.Y284H	DO229224	THCA	ICGC	PPGY	ITCH	0.7229
p.L286F	DO228961	LICA	ICGC	PPGY	ITCH	0.2778
p.R287W	KYSE-150	oesophagus	COSMIC	PPGY	ITCH	0.25
p.I277V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	0.2222
p.I277V	ACH-000951	Lung Cancer	CCLE	PPGY	ITCH	0.2222
p.I277V	NCI-H2342	lung	COSMIC	PPGY	ITCH	0.2222
p.D289E	DO229025	LICA	ICGC	PPGY	ITCH	0.1944
p.R275Q	HCC202	breast	COSMIC	PPGY	ITCH	0.1667
p.P274S	DO220882	MELA	ICGC	PPGY	ITCH	0.1389
p.P274S	DO229459	SKCA	ICGC	PPGY	ITCH	0.1389
p.P274S	SIDM00973	Melanoma	GDSC	PPGY	ITCH	0.1389
p.P274S	ACH-000827	Skin Cancer	CCLE	PPGY	ITCH	0.1389
p.P274S	WM793B	skin	COSMIC	PPGY	ITCH	0.1389
p.P274L	DO229459	SKCA	ICGC	PPGY	ITCH	0.1389
p.W292L	TCGA-ER-A196	SKCM	TCGA	PPGY	ITCH	0.1111
p.W292L	DO47474	SKCM	ICGC	PPGY	ITCH	0.1111

Showing 1 to 19 of 19 entries

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Drug responses associated with RABEP2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPGY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95622	Adenylate cyclase type 5	ITCH	9:12	PPGY	ITCH,NEDD4	0.9301	More...
Q9BTX7	Alpha-tocopherol transfer protein-like	ITCH	28:31	PPGY	ITCH,NEDD4	0.9959	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	912:915	PPGY	ITCH,NEDD4	0.9986	More...
P54259	Atrophin-1	ITCH	654:657	PPGY	ITCH,NEDD4	0.9979	More...
P54259	Atrophin-1	ITCH	670:673	PPGY	ITCH,NEDD4	0.9978	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	1088:1091	PPGY	ITCH,NEDD4	0.9811	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1129:1132	PPGY	ITCH,NEDD4	0.621	More...
P11274	Breakpoint cluster region protein	ITCH	433:436	PPGY	ITCH,NEDD4	0.9994	More...
P27708	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	ITCH	1802:1805	PPGY	ITCH,NEDD4	0.9935	More...
Q9H078	Caseinolytic peptidase B protein homolog	ITCH	427:430	PPGY	ITCH,NEDD4	0.978	More...
P49715	CCAAT/enhancer-binding protein alpha	ITCH	128:131	PPGY	ITCH,NEDD4	0.7286	More...
Q7Z7A1	Centriolin	ITCH	1241:1244	PPGY	ITCH,NEDD4	0.5834	More...
Q12873	Chromodomain-helicase-DNA-binding protein 3	ITCH	1928:1931	PPGY	ITCH,NEDD4	0.7534	More...
P02462	Collagen alpha-1	ITCH	605:608	PPGY	ITCH,NEDD4	0.6191	More...
Q07092	Collagen alpha-1	ITCH	1542:1545	PPGY	ITCH,NEDD4	0.9879	More...
Q2UY09	Collagen alpha-1	ITCH	703:706	PPGY	ITCH,NEDD4	0.9911	More...
Q99715	Collagen alpha-1	ITCH	3040:3043	PPGY	ITCH,NEDD4	0.9593	More...
Q14055	Collagen alpha-2	ITCH	563:566	PPGY	ITCH,NEDD4	0.9513	More...
P25940	Collagen alpha-3	ITCH	705:708	PPGY	ITCH,NEDD4	0.9233	More...
Q01955	Collagen alpha-3	ITCH	615:618	PPGY	ITCH,NEDD4	0.605	More...
Q14050	Collagen alpha-3	ITCH	579:582	PPGY	ITCH,NEDD4	0.7798	More...
P53420	Collagen alpha-4	ITCH	1308:1311	PPGY	ITCH,NEDD4	0.6498	More...
Q5VXM1	CUB domain-containing protein 2	ITCH	290:293	PPGY	ITCH,NEDD4	0.707	More...
Q5JSL3	Dedicator of cytokinesis protein 11	ITCH	782:785	PPGY	ITCH,NEDD4	0.5608	More...
Q92796	Disks large homolog 3	ITCH	27:30	PPGY	ITCH,NEDD4	0.8861	More...

Showing 1 to 25 of 106 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGY

Degron related mutations and impact score

Drug responses associated with RABEP2 mutations

All proteins holding degron of PPGY