DegronMD - P02462(COL4A1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1129H	TCGA-95-7567	LUAD	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.1111
p.P1129H	DO25564	LUAD	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.1111
p.P1138S	TCGA-99-8025	LUAD	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.5641
p.P1138S	DO24255	LUAD	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.5641
p.G1142D	TCGA-BG-A222	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6087
p.G1142D	DO42977	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6087
p.A611V	TCGA-CV-5442	HNSC	TCGA	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.A611V	DO14678	HNSC	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.G618R	TCGA-D3-A2JL	SKCM	TCGA	PPGY	ITCH	605:608	Mutation rewiring degron network	0.0556
p.G618R	DO47278	SKCM	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.0556
p.P1138H	TCGA-EO-A22U	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1138H	DO43755	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1138H	SIDM00238	Ovarian Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1138H	ACH-000947	Ovarian Cancer	CCLE	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1138H	OVK-18	ovary	COSMIC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1143H	TCGA-ER-A19N	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.P1143H	DO37452	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6583
p.K1132R	TCGA-EY-A3QX	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation substituting flanking lysine	0.3056
p.K1132R	DO48176	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation substituting flanking lysine	0.3056
p.E1152K	TCGA-FW-A3R5	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.1111
p.E1152K	DO37406	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.1111
p.G1133E	TCGA-FW-A3R5	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.2222
p.G1133E	DO222644	MELA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.2222
p.G1133E	DO37406	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.2222
p.R597C	TCGA-LC-A66R	BLCA	TCGA	PPGY	ITCH	605:608	Mutation rewiring degron network	0.1111
p.R597C	DO44031	BLCA	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.1111
p.G601A	DO222874	COCA	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.2222
p.P1141L	DO233760	GACA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.7582
p.P613T	DO229019	LICA	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.1944
p.G1139E	DO222843	MELA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.6087
p.P613L	DO232826	NACA	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.1944
p.A611T	DO232829	NACA	ICGC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.A1135V	DO229259	THCA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation rewiring degron network	0.2778
p.P602L	SIDM01175	Other Sarcomas	GDSC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.P602L	ACH-002309	Sarcoma	CCLE	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.P602L	SW684	soft tissue	COSMIC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.25
p.G601S	SIDM00660	Colorectal Carcinoma	GDSC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.2222
p.G601S	ACH-000985	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	605:608	Mutation rewiring degron network	0.2222
p.G601S	LS-411N	large intestine	COSMIC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.2222
p.T1144R	SIDM00192	Colorectal Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.7876
p.T1144R	SIDM01728	Endometrial Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.7876
p.T1144R	SIDM01463	Endometrial Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.7876
p.T1144R	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	1137:1144	Mutation altering degron motif	0.7876
p.G595C	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	605:608	Mutation rewiring degron network	0.0556
p.G595C	ACH-000925	Lung Cancer	CCLE	PPGY	ITCH	605:608	Mutation rewiring degron network	0.0556

Kaplan plot for COL4A1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL4A1

UniProt ID: P02462

Entrez ID: 1282

Protein name: Collagen alpha-1(IV) chain [Cleaved into: Arresten]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for COL4A1 in