DegronMD

Uniprot ID: P02462

Source protein: Collagen alpha-1

Source gene: COL4A1

Class: DEG_SCF_FBW7_1

Location: 1137:1144

E3 ligase: FBXW7

DEGRON score: 0.9744

ASA_SCORE: 70.3375

COIL: 0.9426

CONS_SCORE: 0.7033

DSS_SCORE: 0.7935

HELIX: 0.0079

FCONS_SCORE: 0.9872

RIG_SCORE: 0.5371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1129H	TCGA-95-7567	LUAD	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.1111
p.P1129H	DO25564	LUAD	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.1111
p.P1138S	TCGA-99-8025	LUAD	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.5641
p.P1138S	DO24255	LUAD	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.5641
p.G1142D	TCGA-BG-A222	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.6087
p.G1142D	DO42977	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.6087
p.P1138H	TCGA-EO-A22U	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1138H	DO43755	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1138H	SIDM00238	Ovarian Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1138H	ACH-000947	Ovarian Cancer	CCLE	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1138H	OVK-18	ovary	COSMIC	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1143H	TCGA-ER-A19N	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.P1143H	DO37452	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.6583
p.K1132R	TCGA-EY-A3QX	UCEC	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.3056
p.K1132R	DO48176	UCEC	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.3056
p.E1152K	TCGA-FW-A3R5	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.1111
p.E1152K	DO37406	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.1111
p.G1133E	TCGA-FW-A3R5	SKCM	TCGA	LPGTPGPT	DEG_SCF_FBW7_1	0.2222
p.G1133E	DO222644	MELA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.2222
p.G1133E	DO37406	SKCM	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.2222
p.P1141L	DO233760	GACA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.7582
p.G1139E	DO222843	MELA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.6087
p.A1135V	DO229259	THCA	ICGC	LPGTPGPT	DEG_SCF_FBW7_1	0.2778
p.T1144R	SIDM00192	Colorectal Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	0.7876
p.T1144R	SIDM01728	Endometrial Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	0.7876
p.T1144R	SIDM01463	Endometrial Carcinoma	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	0.7876
p.T1144R	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LPGTPGPT	DEG_SCF_FBW7_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P02462	Collagen alpha-1	DEG_SCF_FBW7_1	1137:1144	LPGTPGPT	FBXW7	0.9744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPGTPGPT

Degron related mutations and impact score

Drug responses associated with COL4A1 mutations

All proteins holding degron of LPGTPGPT