DegronMD - O15442(MPPED1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N62K	TCGA-44-6774	LUAD	TCGA	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1111
p.N62K	DO25000	LUAD	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1111
p.A83T	TCGA-56-8304	LUSC	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.25
p.A83T	DO219138	LUSC	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.25
p.R91H	TCGA-A5-A0G1	UCEC	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.R91H	DO46342	OV	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.R91H	DO42472	UCEC	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.V79M	TCGA-A5-A0G2	UCEC	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1389
p.R91C	TCGA-AA-A01V	COAD	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2778
p.V95I	TCGA-AZ-4315	COAD	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.V95I	DO48425	BLCA	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.V95I	DO8842	COAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.I63N	TCGA-B5-A0JY	UCEC	TCGA	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.0833
p.I63N	DO43041	UCEC	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.0833
p.V93I	TCGA-CJ-4900	KIRC	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	TCGA-EB-A4OY	SKCM	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	DO18711	KIRC	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	DO47261	SKCM	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	SIDM00346	Chronic Myelogenous Leukemia	GDSC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	ACH-000301	Leukemia	CCLE	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.V93I	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.2222
p.D77H	TCGA-CR-7388	HNSC	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0833
p.D77H	DO14284	HNSC	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0833
p.P80H	TCGA-G4-6588	COAD	TCGA	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.P80H	DO10140	COAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.P80H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.P80H	ACH-002272	Lymphoma	CCLE	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.P80H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.T59N	TCGA-RD-A8MV	STAD	TCGA	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1944
p.T59N	DO50133	STAD	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1944
p.P86H	TCGA-VS-A9UR	CESC	TCGA	PPGY	ITCH	86:89	Mutation altering degron motif	0.7694
p.P86H	DO219739	CESC	ICGC	PPGY	ITCH	86:89	Mutation altering degron motif	0.7694
p.T90N	DO225116	BRCA	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.3056
p.T90N	DO227517	BRCA	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.3056
p.R96W	DO44091	COAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1389
p.R96W	DO42368	UCEC	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1389
p.A54T	DO10332	COAD	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.7139
p.A54T	DO42023	UCEC	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.7139
p.V95M	DO230346	COCA	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.S80L	DO50441	ESAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.F61V	DO233093	GACA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1389
p.I38F	DO233697	GACA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.0556
p.D55N	DO22586	LGG	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.3056
p.D49G	DO44559	LGG	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.7198
p.G42C	DO228948	LICA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1667
p.V39L	DO52283	LIHC	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.0833
p.D90V	DO45199	LIRI	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.3056
p.V95L	DO218942	LUAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.1667
p.Q89H	DO219141	LUSC	ICGC	PPGY	ITCH	86:89	Mutation altering degron motif	0.7582
p.A57D	DO222420	MELA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.25
p.E51K	DO222880	MELA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.7022
p.E49A	DO47064	RECA	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.659
p.R99W	DO38715	STAD	ICGC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0556
p.A41T	DO41572	UCEC	ICGC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.1389
p.A57G	SIDM00562	Breast Carcinoma	GDSC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.25
p.A57G	ACH-002163	Breast Cancer	CCLE	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.25
p.A57G	MRK-nu-1	breast	COSMIC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.25
p.A57G	VMRC-RCZ	kidney	COSMIC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.25
p.H99Q	SIDM00498	Colorectal Carcinoma	GDSC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0556
p.H99Q	ACH-000970	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0556
p.H99Q	SNU-C5	large intestine	COSMIC	PPGY	ITCH	86:89	Mutation rewiring degron network	0.0556
p.E46K	SIDM01059	Melanoma	GDSC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.2778
p.E46K	ACH-000915	Skin Cancer	CCLE	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.2778
p.E46K	IPC-298	skin	COSMIC	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.2778
p.P87L	SIDM01511	Gastric Carcinoma	GDSC	PPGY	ITCH	86:89	Mutation altering degron motif	0.7582
p.P87L	ACH-000746	Gastric Cancer	CCLE	PPGY	ITCH	86:89	Mutation altering degron motif	0.7582
p.D48E	SIDM01619	Endometrial Carcinoma	GDSC	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.6758
p.D48E	ACH-000984	Endometrial/Uterine Cancer	CCLE	DEYSSNP	CBL_PTK	48:54	Mutation altering degron motif	0.6758
p.Q39K	ACH-000872	Lung Cancer	CCLE	DEYSSNP	CBL_PTK	48:54	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPPED1

UniProt ID: O15442

Entrez ID: 758

Protein name: Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPPED1 in