DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
DEYSSNP
Uniprot ID:
O15442
Source protein:
Metallophosphoesterase domain-containing protein 1
Source gene:
MPPED1
Class:
CBL_PTK
Location:
48:54
E3 ligase:
CBL
DEGRON score:
0.8939
ASA_SCORE:
57.5714
COIL:
0.7881
CONS_SCORE:
0.4432
DSS_SCORE:
0.2662
HELIX:
0.1294
FCONS_SCORE:
1.0512
RIG_SCORE:
0.7244
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N62K
TCGA-44-6774
LUAD
TCGA
DEYSSNP
CBL_PTK
0.1111
p.N62K
DO25000
LUAD
ICGC
DEYSSNP
CBL_PTK
0.1111
p.I63N
TCGA-B5-A0JY
UCEC
TCGA
DEYSSNP
CBL_PTK
0.0833
p.I63N
DO43041
UCEC
ICGC
DEYSSNP
CBL_PTK
0.0833
p.T59N
TCGA-RD-A8MV
STAD
TCGA
DEYSSNP
CBL_PTK
0.1944
p.T59N
DO50133
STAD
ICGC
DEYSSNP
CBL_PTK
0.1944
p.A54T
DO10332
COAD
ICGC
DEYSSNP
CBL_PTK
0.7139
p.A54T
DO42023
UCEC
ICGC
DEYSSNP
CBL_PTK
0.7139
p.F61V
DO233093
GACA
ICGC
DEYSSNP
CBL_PTK
0.1389
p.I38F
DO233697
GACA
ICGC
DEYSSNP
CBL_PTK
0.0556
p.D55N
DO22586
LGG
ICGC
DEYSSNP
CBL_PTK
0.3056
p.D49G
DO44559
LGG
ICGC
DEYSSNP
CBL_PTK
0.7198
p.G42C
DO228948
LICA
ICGC
DEYSSNP
CBL_PTK
0.1667
p.V39L
DO52283
LIHC
ICGC
DEYSSNP
CBL_PTK
0.0833
p.A57D
DO222420
MELA
ICGC
DEYSSNP
CBL_PTK
0.25
p.E51K
DO222880
MELA
ICGC
DEYSSNP
CBL_PTK
0.7022
p.E49A
DO47064
RECA
ICGC
DEYSSNP
CBL_PTK
0.659
p.A41T
DO41572
UCEC
ICGC
DEYSSNP
CBL_PTK
0.1389
p.A57G
SIDM00562
Breast Carcinoma
GDSC
DEYSSNP
CBL_PTK
0.25
p.A57G
ACH-002163
Breast Cancer
CCLE
DEYSSNP
CBL_PTK
0.25
p.A57G
MRK-nu-1
breast
COSMIC
DEYSSNP
CBL_PTK
0.25
p.A57G
VMRC-RCZ
kidney
COSMIC
DEYSSNP
CBL_PTK
0.25
p.E46K
SIDM01059
Melanoma
GDSC
DEYSSNP
CBL_PTK
0.2778
p.E46K
ACH-000915
Skin Cancer
CCLE
DEYSSNP
CBL_PTK
0.2778
p.E46K
IPC-298
skin
COSMIC
DEYSSNP
CBL_PTK
0.2778
p.D48E
SIDM01619
Endometrial Carcinoma
GDSC
DEYSSNP
CBL_PTK
0.6758
p.D48E
ACH-000984
Endometrial/Uterine Cancer
CCLE
DEYSSNP
CBL_PTK
0.6758
p.Q39K
ACH-000872
Lung Cancer
CCLE
DEYSSNP
CBL_PTK
0.0833
Drug responses associated with MPPED1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DEYSSNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15777
Metallophosphoesterase MPPED2
CBL_PTK
16:22
DEYSSNP
CBL
0.9903
More...
O15442
Metallophosphoesterase domain-containing protein 1
CBL_PTK
48:54
DEYSSNP
CBL
0.8939
More...