DegronMD - Q15777(MPPED2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A25V	TCGA-53-7813	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25V	DO24349	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	TCGA-53-7813	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	TCGA-AP-A1DK	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	DO24349	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	DO42033	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.V11F	TCGA-78-7155	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1944
p.V11F	DO23590	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1944
p.D16N	TCGA-A6-6651	COAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5821
p.D16N	DO8328	COAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5821
p.H28N	TCGA-AP-A051	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1667
p.H28N	DO42673	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1667
p.N21T	TCGA-B5-A11U	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5944
p.N21T	DO40804	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5944
p.T14M	TCGA-B5-A3FC	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.T14M	DO41871	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.Q8E	TCGA-CF-A5UA	BLCA	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1111
p.Q8E	DO51871	BLCA	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1111
p.Q8H	TCGA-EE-A3JD	SKCM	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1111
p.Q8H	DO50299	SKCM	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1111
p.G9C	TCGA-NJ-A55R	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1389
p.G9C	DO218947	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1389
p.Q24K	DO228974	LICA	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.Q8K	DO229015	LICA	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1111
p.V15M	SIDM00305	Ovarian Carcinoma	GDSC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.3056
p.V15M	ACH-000132	Ovarian Cancer	CCLE	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.3056
p.T12A	SIDM00282	Colorectal Carcinoma	GDSC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222
p.T12A	ACH-000998	Colon/Colorectal Cancer	CCLE	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222
p.T12A	CW-2	large intestine	COSMIC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222

Kaplan plot for MPPED2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPPED2

UniProt ID: Q15777

Entrez ID: 744

Protein name: Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPPED2 in