DegronMD - Q15777(MPPED2)

FUNCTION: Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system. {ECO:0000250|UniProtKB:B1WBP0}.

GO - Biological processes (BP):

GO - Molecular function (MF): AMP binding [GO:0016208]; GMP binding [GO:0019002]; manganese ion binding [GO:0030145]; phosphoric diester hydrolase activity [GO:0008081]

GO - Cellular component (CC):

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DEYSSNP	CBL_PTK	CBL	Metallophosphoesterase MPPED2	16:22	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N21T	TCGA-B5-A11U	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5944
p.N21T	DO40804	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5944
p.D16N	TCGA-A6-6651	COAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5821
p.D16N	DO8328	COAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation altering degron motif	0.5821
p.V15M	SIDM00305	Ovarian Carcinoma	GDSC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.3056
p.V15M	ACH-000132	Ovarian Cancer	CCLE	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.3056
p.T14M	TCGA-B5-A3FC	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.T14M	DO41871	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.Q24K	DO228974	LICA	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2778
p.A25V	TCGA-53-7813	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25V	DO24349	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	TCGA-53-7813	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	TCGA-AP-A1DK	UCEC	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	DO24349	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.A25S	DO42033	UCEC	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.25
p.T12A	SIDM00282	Colorectal Carcinoma	GDSC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222
p.T12A	ACH-000998	Colon/Colorectal Cancer	CCLE	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222
p.T12A	CW-2	large intestine	COSMIC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.2222
p.V11F	TCGA-78-7155	LUAD	TCGA	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1944
p.V11F	DO23590	LUAD	ICGC	DEYSSNP	CBL_PTK	16:22	Mutation rewiring degron network	0.1944

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Kaplan plot for MPPED2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPPED2

UniProt ID: Q15777

Entrez ID: 744

Protein name: Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Fetal brain protein 239) (239FB) (Metallophosphoesterase domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPPED2 in