DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DEYSSNP
Uniprot ID:
Q15777
Source protein:
Metallophosphoesterase MPPED2
Source gene:
MPPED2
Class:
CBL_PTK
Location:
16:22
E3 ligase:
CBL
DEGRON score:
0.9903
ASA_SCORE:
61.5
COIL:
0.8251
CONS_SCORE:
0.464
DSS_SCORE:
0.4143
HELIX:
0.1447
FCONS_SCORE:
1.0571
RIG_SCORE:
0.7203
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A25V
TCGA-53-7813
LUAD
TCGA
DEYSSNP
CBL_PTK
0.25
p.A25V
DO24349
LUAD
ICGC
DEYSSNP
CBL_PTK
0.25
p.A25S
TCGA-53-7813
LUAD
TCGA
DEYSSNP
CBL_PTK
0.25
p.A25S
TCGA-AP-A1DK
UCEC
TCGA
DEYSSNP
CBL_PTK
0.25
p.A25S
DO24349
LUAD
ICGC
DEYSSNP
CBL_PTK
0.25
p.A25S
DO42033
UCEC
ICGC
DEYSSNP
CBL_PTK
0.25
p.V11F
TCGA-78-7155
LUAD
TCGA
DEYSSNP
CBL_PTK
0.1944
p.V11F
DO23590
LUAD
ICGC
DEYSSNP
CBL_PTK
0.1944
p.D16N
TCGA-A6-6651
COAD
TCGA
DEYSSNP
CBL_PTK
0.5821
p.D16N
DO8328
COAD
ICGC
DEYSSNP
CBL_PTK
0.5821
p.H28N
TCGA-AP-A051
UCEC
TCGA
DEYSSNP
CBL_PTK
0.1667
p.H28N
DO42673
UCEC
ICGC
DEYSSNP
CBL_PTK
0.1667
p.N21T
TCGA-B5-A11U
UCEC
TCGA
DEYSSNP
CBL_PTK
0.5944
p.N21T
DO40804
UCEC
ICGC
DEYSSNP
CBL_PTK
0.5944
p.T14M
TCGA-B5-A3FC
UCEC
TCGA
DEYSSNP
CBL_PTK
0.2778
p.T14M
DO41871
UCEC
ICGC
DEYSSNP
CBL_PTK
0.2778
p.Q8E
TCGA-CF-A5UA
BLCA
TCGA
DEYSSNP
CBL_PTK
0.1111
p.Q8E
DO51871
BLCA
ICGC
DEYSSNP
CBL_PTK
0.1111
p.Q8H
TCGA-EE-A3JD
SKCM
TCGA
DEYSSNP
CBL_PTK
0.1111
p.Q8H
DO50299
SKCM
ICGC
DEYSSNP
CBL_PTK
0.1111
p.G9C
TCGA-NJ-A55R
LUAD
TCGA
DEYSSNP
CBL_PTK
0.1389
p.G9C
DO218947
LUAD
ICGC
DEYSSNP
CBL_PTK
0.1389
p.Q24K
DO228974
LICA
ICGC
DEYSSNP
CBL_PTK
0.2778
p.Q8K
DO229015
LICA
ICGC
DEYSSNP
CBL_PTK
0.1111
p.V15M
SIDM00305
Ovarian Carcinoma
GDSC
DEYSSNP
CBL_PTK
0.3056
p.V15M
ACH-000132
Ovarian Cancer
CCLE
DEYSSNP
CBL_PTK
0.3056
p.T12A
SIDM00282
Colorectal Carcinoma
GDSC
DEYSSNP
CBL_PTK
0.2222
p.T12A
ACH-000998
Colon/Colorectal Cancer
CCLE
DEYSSNP
CBL_PTK
0.2222
p.T12A
CW-2
large_intestine
COSMIC
DEYSSNP
CBL_PTK
0.2222
Drug responses associated with MPPED2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DEYSSNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15777
Metallophosphoesterase MPPED2
CBL_PTK
16:22
DEYSSNP
CBL
0.9903
More...
O15442
Metallophosphoesterase domain-containing protein 1
CBL_PTK
48:54
DEYSSNP
CBL
0.8939
More...