DegronMD - Q92796(DLG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T584M	TCGA-A5-A0G1	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.1944
p.T584M	TCGA-AJ-A3BG	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.1944
p.K569R	TCGA-A7-A425	BRCA	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.R24C	TCGA-AY-A71X	COAD	TCGA	PPGY	ITCH	27:30	Mutation rewiring degron network	0.25
p.R24C	DO51726	COAD	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.25
p.P562H	TCGA-BF-A1Q0	SKCM	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.0833
p.P562H	TCGA-BF-A1Q0	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation rewiring degron network	0.1111
p.P562H	TCGA-CR-5248	HNSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.0833
p.P562H	TCGA-CR-5248	HNSC	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation rewiring degron network	0.1111
p.D541E	TCGA-BF-AAP2	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation rewiring degron network	0.1111
p.G553R	TCGA-D1-A15X	UCEC	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation altering degron motif	0.6457
p.G553R	TCGA-FI-A2D5	UCEC	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation altering degron motif	0.6457
p.G553R	SIDM01175	Other Sarcomas	GDSC	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation altering degron motif	0.6457
p.G553R	SW684	soft tissue	COSMIC	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation altering degron motif	0.6457
p.S539Y	TCGA-EE-A2GJ	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation rewiring degron network	0.0556
p.K569N	TCGA-FI-A2D5	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.2778
p.T550S	TCGA-YA-A8S7	LIHC	TCGA	VTPHGE	LIG_APCC_ABBA_1	549:554	Mutation altering degron motif	0.7116
p.S28L	DO50034	BRCA	ICGC	PPGY	ITCH	27:30	Mutation altering degron motif	0.7667
p.S28L	DO37750	SKCM	ICGC	PPGY	ITCH	27:30	Mutation altering degron motif	0.7667
p.A19G	DO2665	BRCA	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.R36C	DO51616	CESC	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1667
p.L38M	DO15198	HNSC	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.L38M	DO47303	SKCM	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.W33C	DO228952	LICA	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.25
p.W33R	DO228901	LICA	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.25
p.D37V	DO28119	OV	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1389
p.R25M	DO49398	PAAD	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.2778
p.R19S	DO219987	SARC	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.S20F	DO37406	SKCM	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1389
p.A21T	DO38603	STAD	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1667
p.S18P	DO229250	THCA	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.0833
p.R31Q	DO42608	UCEC	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.3056
p.S39N	DO41133	UCEC	ICGC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.0833
p.A19T	SIDM01314	Colorectal Carcinoma	GDSC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.T577N	SIDM01624	Bladder Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.5944
p.T577N	SIDM01529	Bladder Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.5944
p.A32V	SIDM01619	Endometrial Carcinoma	GDSC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.2778
p.P38H	ACH-000851	Lung Cancer	CCLE	PPGY	ITCH	27:30	Mutation rewiring degron network	0.1111
p.G571R	ACH-002309	Sarcoma	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7568
p.G571R	SW684	soft tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.7568
p.E17K	MCC13	skin	COSMIC	PPGY	ITCH	27:30	Mutation rewiring degron network	0.0556

Kaplan plot for DLG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLG3

UniProt ID: Q92796

Entrez ID: 1741

Protein name: Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLG3 in