DegronMD

Uniprot ID: Q92796

Source protein: Disks large homolog 3

Source gene: DLG3

Class: DEG_APCC_DBOX_1

Location: 571:579

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9168

ASA_SCORE: 102.2556

COIL: 0.3639

CONS_SCORE: 0.6228

DSS_SCORE: 0.4427

HELIX: 0.6201

FCONS_SCORE: 1.0258

RIG_SCORE: 0.7955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T584M	TCGA-A5-A0G1	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1944
p.T584M	TCGA-AJ-A3BG	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1944
p.K569R	TCGA-A7-A425	BRCA	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.2778
p.P562H	TCGA-BF-A1Q0	SKCM	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.P562H	TCGA-CR-5248	HNSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.K569N	TCGA-FI-A2D5	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.2778
p.T577N	SIDM01624	Bladder Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.5944
p.T577N	SIDM01529	Bladder Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.5944
p.G571R	ACH-002309	Sarcoma	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	0.7568
p.G571R	SW684	soft_tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons