DegronMD

Uniprot ID: Q12959

Source protein: Disks large homolog 1

Source gene: DLG1

Class: DEG_APCC_DBOX_1

Location: 651:659

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 98.1444

COIL: 0.3172

CONS_SCORE: 0.6357

DSS_SCORE: 0.5098

HELIX: 0.676

FCONS_SCORE: 1.08

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E648V	TCGA-22-0940	LUSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.R645C	TCGA-A5-A1OF	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.R645C	TCGA-FD-A6TB	BLCA	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.T664M	TCGA-AJ-A3BH	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1944
p.S662Y	TCGA-D1-A17Q	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.6944
p.R642S	DO229031	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.R642S	DO229038	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.T664K	DO229008	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.1944
p.S648F	DO222731	MELA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.R645H	ACH-000918	Leukemia	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.N661K	MCC13	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.2778
p.E650D	NCI-H1623	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.3056
p.R649Q	IM-95	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.2778
p.R642H	SNU-1040	large_intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.R648Q	IM-95	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.H660Q	ECC12	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.3056
p.R641H	SNU-1040	large_intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons