DegronMD - Q12959(DLG1)

GO - Biological processes (BP): actin filament organization [GO:0007015]; activation of protein kinase activity [GO:0032147]; amyloid precursor protein metabolic process [GO:0042982]; astral microtubule organization [GO:0030953]; bicellular tight junction assembly [GO:0070830]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell adhesion [GO:0098609]; chemical synaptic transmission [GO:0007268]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell proliferation [GO:0001935]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; hard palate development [GO:0060022]; immunological synapse formation [GO:0001771]; lens development in camera-type eye [GO:0002088]; membrane raft organization [GO:0031579]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0099645]; peristalsis [GO:0030432]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein-containing complex localization [GO:0031503]; protein localization to plasma membrane [GO:0072659]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; regulation of myelination [GO:0031641]; regulation of potassium ion export across plasma membrane [GO:1903764]; regulation of potassium ion import [GO:1903286]; regulation of protein localization to synapse [GO:1902473]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903760]; reproductive structure development [GO:0048608]; smooth muscle tissue development [GO:0048745]; T cell activation [GO:0042110] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E648V	TCGA-22-0940	LUSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.25
p.R645C	TCGA-A5-A1OF	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.1667
p.R645C	TCGA-FD-A6TB	BLCA	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.1667
p.T664M	TCGA-AJ-A3BH	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.1944
p.R587I	TCGA-AP-A1DR	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.S662Y	TCGA-D1-A17Q	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation blocking phosphorylation signal	0.6944
p.E622K	TCGA-EE-A3JB	SKCM	TCGA	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1389
p.L589I	TCGA-FS-A1ZG	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.1111
p.P601S	TCGA-YG-AA3O	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation altering degron motif	0.5641
p.R612C	DO51879	BLCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.R612C	DO42568	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.G624E	DO219002	BLCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1944
p.F638L	DO4018	BRCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.2222
p.D587G	DO229329	BTCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.A620V	DO230343	COCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.0833
p.V596G	DO228536	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.3056
p.D603N	DO233208	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.3056
p.T624K	DO229029	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1944
p.T624K	DO229009	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1944
p.Q636K	DO229028	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.2778
p.Q595K	DO229022	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.2778
p.R642S	DO229031	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.0833
p.R642S	DO229031	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1111
p.R642S	DO229038	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.0833
p.R642S	DO229038	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1111
p.A620D	DO229031	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.0833
p.D587N	DO229050	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.D587N	DO222837	MELA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.0556
p.T664K	DO229008	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.1944
p.S648F	DO222731	MELA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.25
p.P620S	DO51254	SKCM	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.0833
p.E589K	DO51250	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.1111
p.T631M	DO41638	UCEC	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation altering degron motif	0.7423
p.S629Y	DO41903	UCEC	ICGC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation altering degron motif	0.712
p.T595N	SIDM00815	Ovarian Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.2778
p.T595N	ACH-001418	Ovarian Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.2778
p.T595N	UWB1_289	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.2778
p.Q628H	ACH-000467	Colon/Colorectal Cancer	CCLE	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.3056
p.Q628H	HCC-56	large intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.3056
p.R645H	ACH-000918	Leukemia	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.1667
p.N608K	MCC13	skin	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation substituting flanking lysine	0.2778
p.P640S	EN	endometrium	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1667
p.N596K	MCC13	skin	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.3056
p.N661K	MCC13	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.2778
p.Q595H	HCC-56	large intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	597:602	Mutation rewiring degron network	0.2778
p.P628S	EN	endometrium	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.3056
p.E638D	NCI-H1623	lung	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.2222
p.E650D	NCI-H1623	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.3056
p.R649Q	IM-95	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.2778
p.R642H	SNU-1040	large intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.0833
p.R642H	SNU-1040	large intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1111
p.R648Q	IM-95	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.25
p.H660Q	ECC12	stomach	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.3056
p.R641H	SNU-1040	large intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	651:659	Mutation rewiring degron network	0.0556
p.R641H	SNU-1040	large intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	629:634	Mutation rewiring degron network	0.1389

Kaplan plot for DLG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLG1

UniProt ID: Q12959

Entrez ID: 1739

Protein name: Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLG1 in