DegronMD

Uniprot ID: Q12959

Source protein: Disks large homolog 1

Source gene: DLG1

Class: DEG_SCF_TRCP1_1

Location: 597:602

E3 ligase: BTRC

DEGRON score: 0.9814

ASA_SCORE: 57.25

COIL: 0.893

CONS_SCORE: 0.6288

DSS_SCORE: 0.2638

HELIX: 0.0652

FCONS_SCORE: 1.0218

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R587I	TCGA-AP-A1DR	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.L589I	TCGA-FS-A1ZG	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.P601S	TCGA-YG-AA3O	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.5641
p.R612C	DO51879	BLCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.R612C	DO42568	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.D587G	DO229329	BTCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.V596G	DO228536	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.D603N	DO233208	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.Q595K	DO229022	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.D587N	DO229050	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.D587N	DO222837	MELA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.E589K	DO51250	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.T595N	SIDM00815	Ovarian Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.T595N	ACH-001418	Ovarian Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.T595N	UWB1_289	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.N608K	MCC13	skin	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.N596K	MCC13	skin	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.Q595H	HCC-56	large_intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons