DegronMD - Q6PJ61(FBXO46)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P286S	TCGA-D1-A17H	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1667
p.P286S	DO41847	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1667
p.G281V	TCGA-D3-A3C7	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.3056
p.G281V	DO47569	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.3056
p.G283V	TCGA-FS-A1ZJ	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.25
p.G283V	DO37956	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.25
p.G277D	TCGA-HD-7832	HNSC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation altering degron motif	0.7198
p.G277D	DO16061	HNSC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation altering degron motif	0.7198
p.G268S	DO222874	COCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1389
p.G268S	ACH-000883	Brain Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1389
p.R272C	DO50786	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.25
p.G268D	SIDM01609	Endometrial Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1389
p.G268D	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	275:280	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons