DegronMD

Uniprot ID: Q6PJ61

Source protein: F-box only protein 46

Source gene: FBXO46

Class: DEG_SCF_TRCP1_1

Location: 275:280

E3 ligase: BTRC

DEGRON score: 0.9898

ASA_SCORE: 78.6667

COIL: 0.958

CONS_SCORE: 0.418

DSS_SCORE: 0.7204

HELIX: 0.0237

FCONS_SCORE: 0.897

RIG_SCORE: 0.5398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P286S	TCGA-D1-A17H	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.1667
p.P286S	DO41847	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.1667
p.G281V	TCGA-D3-A3C7	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.G281V	DO47569	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.G283V	TCGA-FS-A1ZJ	SKCM	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.G283V	DO37956	SKCM	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.G277D	TCGA-HD-7832	HNSC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.7198
p.G277D	DO16061	HNSC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.7198
p.G268S	DO222874	COCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.G268S	ACH-000883	Brain Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.R272C	DO50786	LICA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.G268D	SIDM01609	Endometrial Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.G268D	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons