DegronMD

Uniprot ID: Q9GZQ6

Source protein: Neuropeptide FF receptor 1

Source gene: NPFFR1

Class: DEG_SCF_TRCP1_1

Location: 380:385

E3 ligase: BTRC

DEGRON score: 0.9245

ASA_SCORE: 87.6

COIL: 0.9492

CONS_SCORE: 0.2834

DSS_SCORE: 0.6121

HELIX: 0.0302

FCONS_SCORE: 0.9492

RIG_SCORE: 0.5616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D380N	DO225046	BRCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.6932
p.R371W	DO229389	BTCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0833
p.R371W	DO234401	ESAD	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.0833
p.S391R	DO50346	ESAD	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.1667
p.R377Q	DO228322	MALY	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.R377Q	SIDM00867	Glioblastoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.R377Q	ACH-001636	Lymphoma	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.R377W	SIDM00582	Pancreatic Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.R377W	SIDM00589	Oral Cavity Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.S379N	ACH-000975	Lung Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons