DegronMD

Uniprot ID: Q15700

Source protein: Disks large homolog 2

Source gene: DLG2

Class: DEG_SCF_TRCP1_1

Location: 552:557

E3 ligase: BTRC

DEGRON score: 0.7664

ASA_SCORE: 52.5833

COIL: 0.8845

CONS_SCORE: 0.62

DSS_SCORE: 0.2839

HELIX: 0.0693

FCONS_SCORE: 1.0647

RIG_SCORE: 0.6787

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P559S	TCGA-AA-A02R	COAD	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.2778
p.A556T	TCGA-F4-6570	COAD	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.7139
p.D545N	TCGA-FI-A2D0	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.D545H	TCGA-K4-A6MB	BLCA	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.D545H	DO44077	BLCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.1389
p.Q567H	TCGA-UF-A71A	HNSC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.Q567H	SIDM00381	Cervical Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.Q567H	SKG-IIIa	cervix	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.M551I	DO51623	CESC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.3056
p.K548N	DO233807	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.2222
p.F552S	DO42023	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	0.7982
p.A560S	SIDM00789	Colorectal Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.A560S	HCT-15	large_intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.25
p.G548C	SIDM00282	Colorectal Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.2222
p.G548C	CW-2	large_intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.2222
p.G542S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.G542S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.0556
p.E565D	SIDM00815	Ovarian Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.E565D	UWB1_289	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.S553R	ACH-000872	Lung Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.8538
p.M544I	ACH-000885	Ovarian Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.M544I	TOV-21G	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.S557I	ACH-000887	Brain Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	0.7341
p.Q557R	NCI-H1355	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.7329
p.G555R	NCI-H1770	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.7568
p.E544D	RKO	large_intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.1111
p.K557I	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.7531
p.D543G	CW-2	large_intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.0833
p.R546S	NCI-H1734	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12959	Disks large homolog 1	DEG_SCF_TRCP1_1	597:602	DSGLPS	BTRC	0.9814	More...
Q15700	Disks large homolog 2	DEG_SCF_TRCP1_1	552:557	DSGLPS	BTRC	0.7664	More...
Q9GZQ6	Neuropeptide FF receptor 1	DEG_SCF_TRCP1_1	380:385	DSGLPS	BTRC	0.9245	More...
Q6PJ61	F-box only protein 46	DEG_SCF_TRCP1_1	275:280	DSGLPS	BTRC	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGLPS

Degron related mutations and impact score

Drug responses associated with DLG2 mutations

All proteins holding degron of DSGLPS