DegronMD - Q15700(DLG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q597E	TCGA-43-6770	LUSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.0833
p.A338V	TCGA-AA-3845	COAD	TCGA	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.6936
p.Y328F	TCGA-AA-A00N	COAD	TCGA	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.0833
p.P559S	TCGA-AA-A02R	COAD	TCGA	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.2778
p.R612Q	TCGA-B5-A0JY	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7329
p.L351P	TCGA-BR-6852	STAD	TCGA	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1389
p.G342R	TCGA-D3-A3CB	SKCM	TCGA	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7568
p.R621Q	TCGA-D3-A51T	SKCM	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1389
p.A556T	TCGA-F4-6570	COAD	TCGA	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7139
p.D545N	TCGA-FI-A2D0	UCEC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1389
p.D545H	TCGA-K4-A6MB	BLCA	TCGA	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1389
p.D545H	DO44077	BLCA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1389
p.Q567H	TCGA-UF-A71A	HNSC	TCGA	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0556
p.Q567H	SIDM00381	Cervical Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0556
p.Q567H	SKG-IIIa	cervix	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0556
p.R599H	DO219030	BLCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation substituting flanking lysine	0.25
p.F611L	DO481	BLCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.6981
p.F611L	HCC2998	large intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.6981
p.M551I	DO51623	CESC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.3056
p.A340T	DO51621	CESC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7139
p.D337G	DO9010	COAD	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7198
p.D337G	DO222816	COCA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7198
p.V352I	DO230343	COCA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.P345S	DO227686	COCA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.3056
p.A611T	DO227904	COCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7139
p.A611T	SIDM01943	Colorectal Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7139
p.G352V	DO233249	GACA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.K548N	DO233807	GACA	ICGC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.2222
p.Q606K	DO229019	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.6944
p.S347T	DO23624	LUAD	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.25
p.R350P	DO231016	LUSC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1667
p.W327C	DO26520	LUSC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation blocking phosphorylation signal	0.5
p.M346I	DO26790	LUSC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.2778
p.S343L	DO222363	MELA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7667
p.E332K	DO222382	MELA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation substituting flanking lysine	0.3056
p.E332K	DO222702	MELA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation substituting flanking lysine	0.3056
p.E332K	DO37432	SKCM	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation substituting flanking lysine	0.3056
p.E330K	DO229502	SKCA	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1389
p.P329S	DO37996	SKCM	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.P329S	DO43971	UCEC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.Q617H	DO47374	SKCM	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.25
p.F552S	DO42023	UCEC	ICGC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7982
p.K331N	DO223282	UCEC	ICGC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1667
p.T622A	DO42713	UCEC	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1111
p.T600M	SIDM00373	Endometrial Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1667
p.T600M	SNG-M	endometrium	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1667
p.A560S	SIDM00789	Colorectal Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.25
p.A560S	HCT-15	large intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.25
p.Q623R	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.0833
p.Q623R	NCI-H1355	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.0833
p.D609G	SIDM00282	Colorectal Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7198
p.D609G	CW-2	large intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7198
p.G548C	SIDM00282	Colorectal Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.2222
p.G548C	CW-2	large intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.2222
p.G336V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.3056
p.G336V	H513	pleura	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.3056
p.G542S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0556
p.G542S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0556
p.E565D	SIDM00815	Ovarian Carcinoma	GDSC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1111
p.E565D	UWB1_289	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1111
p.Q597P	SIDM00996	Thyroid Gland Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.0833
p.Q597P	8505C	thyroid	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.0833
p.L620I	SIDM01608	Endometrial Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1667
p.R607S	ACH-000675	Lung Cancer	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7427
p.R607S	NCI-H1734	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7427
p.S553R	ACH-000872	Lung Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.8538
p.M544I	ACH-000885	Ovarian Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1111
p.M544I	TOV-21G	ovary	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1111
p.S557I	ACH-000887	Brain Cancer	CCLE	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7341
p.K618I	ACH-000944	Lymphoma	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation substituting flanking lysine	0.3333
p.K618I	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation substituting flanking lysine	0.3333
p.S349I	ACH-000945	Lung Cancer	CCLE	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1944
p.S349I	NCI-H650	lung	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1944
p.V602A	ACH-000978	Endometrial/Uterine Cancer	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.2222
p.V602A	EN	endometrium	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.2222
p.Y348H	ACH-000998	Colon/Colorectal Cancer	CCLE	DDDYTRPP	CBL_PTK	337:344	Mutation blocking phosphorylation signal	0.6667
p.Y348H	CW-2	large intestine	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation blocking phosphorylation signal	0.6667
p.M334K	ACH-001232	Brain Cancer	CCLE	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.25
p.P344S	ACH-002256	Leukemia	CCLE	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.6752
p.P344S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.6752
p.P329L	SW48	large intestine	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.R342H	SISO	cervix	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7133
p.S346F	NCI-H1770	lung	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.2778
p.G340C	CW-2	large intestine	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.76
p.A352S	HCT-15	large intestine	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1111
p.R599S	NCI-H128	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation substituting flanking lysine	0.25
p.G334S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.25
p.P610Q	SR	haematopoietic and lymphoid tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7035
p.Q557R	NCI-H1355	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7329
p.G555R	NCI-H1770	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7568
p.T339N	UACC-893	breast	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation altering degron motif	0.7055
p.E330D	Daudi	haematopoietic and lymphoid tissue	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1389
p.E616D	RKO	large intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.2778
p.E544D	RKO	large intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1111
p.E621K	Mewo	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation rewiring degron network	0.1389
p.K557I	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation altering degron motif	0.7531
p.D543G	CW-2	large intestine	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.0833
p.E335D	SK-MG-1	central nervous system	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.2778
p.L618F	DJM-1	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation substituting flanking lysine	0.3333
p.R350W	SNU-C5	large intestine	COSMIC	DDDYTRPP	CBL_PTK	337:344	Mutation rewiring degron network	0.1667
p.M610I	BICR22	upper aerodigestive tract	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	606:614	Mutation altering degron motif	0.7618
p.R546S	NCI-H1734	lung	COSMIC	DSGLPS	DEG_SCF_TRCP1_1	552:557	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLG2

UniProt ID: Q15700

Entrez ID: 1740

Protein name: Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLG2 in