DegronMD

Uniprot ID: Q15700

Source protein: Disks large homolog 2

Source gene: DLG2

Class: DEG_APCC_DBOX_1

Location: 606:614

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7873

ASA_SCORE: 101.0444

COIL: 0.3374

CONS_SCORE: 0.6245

DSS_SCORE: 0.4195

HELIX: 0.6513

FCONS_SCORE: 1.0163

RIG_SCORE: 0.791

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q597E	TCGA-43-6770	LUSC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.R612Q	TCGA-B5-A0JY	UCEC	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.7329
p.R621Q	TCGA-D3-A51T	SKCM	TCGA	ERARLKTVK	DEG_APCC_DBOX_1	0.1389
p.R599H	DO219030	BLCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.F611L	DO481	BLCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.6981
p.F611L	HCC2998	large_intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.6981
p.A611T	DO227904	COCA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.7139
p.A611T	SIDM01943	Colorectal Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.7139
p.Q606K	DO229019	LICA	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.6944
p.Q617H	DO47374	SKCM	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.T622A	DO42713	UCEC	ICGC	ERARLKTVK	DEG_APCC_DBOX_1	0.1111
p.T600M	SIDM00373	Endometrial Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.T600M	SNG-M	endometrium	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.Q623R	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.Q623R	NCI-H1355	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.D609G	SIDM00282	Colorectal Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.7198
p.D609G	CW-2	large_intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.7198
p.Q597P	SIDM00996	Thyroid Gland Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.Q597P	8505C	thyroid	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.0833
p.L620I	SIDM01608	Endometrial Carcinoma	GDSC	ERARLKTVK	DEG_APCC_DBOX_1	0.1667
p.R607S	ACH-000675	Lung Cancer	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	0.7427
p.R607S	NCI-H1734	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.7427
p.K618I	ACH-000944	Lymphoma	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	0.3333
p.K618I	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.3333
p.V602A	ACH-000978	Endometrial/Uterine Cancer	CCLE	ERARLKTVK	DEG_APCC_DBOX_1	0.2222
p.V602A	EN	endometrium	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.2222
p.R599S	NCI-H128	lung	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.25
p.P610Q	SR	haematopoietic_and_lymphoid_tissue	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.7035
p.E616D	RKO	large_intestine	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.2778
p.E621K	Mewo	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.1389
p.L618F	DJM-1	skin	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.3333
p.M610I	BICR22	upper_aerodigestive_tract	COSMIC	ERARLKTVK	DEG_APCC_DBOX_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12959	Disks large homolog 1	DEG_APCC_DBOX_1	651:659	ERARLKTVK	APC,CDC20,FZR1	0.981	More...
Q15700	Disks large homolog 2	DEG_APCC_DBOX_1	606:614	ERARLKTVK	APC,CDC20,FZR1	0.7873	More...
Q92796	Disks large homolog 3	DEG_APCC_DBOX_1	571:579	ERARLKTVK	APC,CDC20,FZR1	0.9168	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERARLKTVK

Degron related mutations and impact score

Drug responses associated with DLG2 mutations

All proteins holding degron of ERARLKTVK