DegronMD

Uniprot ID: Q15700

Source protein: Disks large homolog 2

Source gene: DLG2

Class: CBL_PTK

Location: 337:344

E3 ligase: CBL

DEGRON score: 0.9897

ASA_SCORE: 87.925

COIL: 0.873

CONS_SCORE: 0.2019

DSS_SCORE: 0.4791

HELIX: 0.0583

FCONS_SCORE: 1.0223

RIG_SCORE: 0.7142

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A338V	TCGA-AA-3845	COAD	TCGA	DDDYTRPP	CBL_PTK	0.6936
p.Y328F	TCGA-AA-A00N	COAD	TCGA	DDDYTRPP	CBL_PTK	0.0833
p.L351P	TCGA-BR-6852	STAD	TCGA	DDDYTRPP	CBL_PTK	0.1389
p.G342R	TCGA-D3-A3CB	SKCM	TCGA	DDDYTRPP	CBL_PTK	0.7568
p.A340T	DO51621	CESC	ICGC	DDDYTRPP	CBL_PTK	0.7139
p.D337G	DO9010	COAD	ICGC	DDDYTRPP	CBL_PTK	0.7198
p.D337G	DO222816	COCA	ICGC	DDDYTRPP	CBL_PTK	0.7198
p.V352I	DO230343	COCA	ICGC	DDDYTRPP	CBL_PTK	0.1111
p.P345S	DO227686	COCA	ICGC	DDDYTRPP	CBL_PTK	0.3056
p.G352V	DO233249	GACA	ICGC	DDDYTRPP	CBL_PTK	0.1111
p.S347T	DO23624	LUAD	ICGC	DDDYTRPP	CBL_PTK	0.25
p.R350P	DO231016	LUSC	ICGC	DDDYTRPP	CBL_PTK	0.1667
p.W327C	DO26520	LUSC	ICGC	DDDYTRPP	CBL_PTK	0.5
p.M346I	DO26790	LUSC	ICGC	DDDYTRPP	CBL_PTK	0.2778
p.S343L	DO222363	MELA	ICGC	DDDYTRPP	CBL_PTK	0.7667
p.E332K	DO222382	MELA	ICGC	DDDYTRPP	CBL_PTK	0.3056
p.E332K	DO222702	MELA	ICGC	DDDYTRPP	CBL_PTK	0.3056
p.E332K	DO37432	SKCM	ICGC	DDDYTRPP	CBL_PTK	0.3056
p.E330K	DO229502	SKCA	ICGC	DDDYTRPP	CBL_PTK	0.1389
p.P329S	DO37996	SKCM	ICGC	DDDYTRPP	CBL_PTK	0.1111
p.P329S	DO43971	UCEC	ICGC	DDDYTRPP	CBL_PTK	0.1111
p.K331N	DO223282	UCEC	ICGC	DDDYTRPP	CBL_PTK	0.1667
p.G336V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DDDYTRPP	CBL_PTK	0.3056
p.G336V	H513	pleura	COSMIC	DDDYTRPP	CBL_PTK	0.3056
p.S349I	ACH-000945	Lung Cancer	CCLE	DDDYTRPP	CBL_PTK	0.1944
p.S349I	NCI-H650	lung	COSMIC	DDDYTRPP	CBL_PTK	0.1944
p.Y348H	ACH-000998	Colon/Colorectal Cancer	CCLE	DDDYTRPP	CBL_PTK	0.6667
p.Y348H	CW-2	large_intestine	COSMIC	DDDYTRPP	CBL_PTK	0.6667
p.M334K	ACH-001232	Brain Cancer	CCLE	DDDYTRPP	CBL_PTK	0.25
p.P344S	ACH-002256	Leukemia	CCLE	DDDYTRPP	CBL_PTK	0.6752
p.P344S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DDDYTRPP	CBL_PTK	0.6752
p.P329L	SW48	large_intestine	COSMIC	DDDYTRPP	CBL_PTK	0.1111
p.R342H	SISO	cervix	COSMIC	DDDYTRPP	CBL_PTK	0.7133
p.S346F	NCI-H1770	lung	COSMIC	DDDYTRPP	CBL_PTK	0.2778
p.G340C	CW-2	large_intestine	COSMIC	DDDYTRPP	CBL_PTK	0.76
p.A352S	HCT-15	large_intestine	COSMIC	DDDYTRPP	CBL_PTK	0.1111
p.G334S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DDDYTRPP	CBL_PTK	0.25
p.T339N	UACC-893	breast	COSMIC	DDDYTRPP	CBL_PTK	0.7055
p.E330D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DDDYTRPP	CBL_PTK	0.1389
p.E335D	SK-MG-1	central_nervous_system	COSMIC	DDDYTRPP	CBL_PTK	0.2778
p.R350W	SNU-C5	large_intestine	COSMIC	DDDYTRPP	CBL_PTK	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DDDYTRPP

Degron related mutations and impact score

Drug responses associated with DLG2 mutations

All proteins holding degron of DDDYTRPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15700	Disks large homolog 2	CBL_PTK	337:344	DDDYTRPP	CBL	0.9897	More...