DegronMD

Uniprot ID: Q12959

Source protein: Disks large homolog 1

Source gene: DLG1

Class: DEG_SCF_FBW7_2

Location: 629:634

E3 ligase: FBXW7

DEGRON score: 0.7714

ASA_SCORE: 76.5

COIL: 0.7958

CONS_SCORE: 0.5826

DSS_SCORE: 0.4754

HELIX: 0.0165

FCONS_SCORE: 0.9123

RIG_SCORE: 0.6936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E622K	TCGA-EE-A3JB	SKCM	TCGA	VTPDGE	DEG_SCF_FBW7_2	0.1389
p.G624E	DO219002	BLCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.1944
p.F638L	DO4018	BRCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.2222
p.A620V	DO230343	COCA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.0833
p.T624K	DO229029	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.1944
p.T624K	DO229009	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.1944
p.Q636K	DO229028	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.2778
p.R642S	DO229031	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.1111
p.R642S	DO229038	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.1111
p.A620D	DO229031	LICA	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.0833
p.P620S	DO51254	SKCM	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.0833
p.T631M	DO41638	UCEC	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.7423
p.S629Y	DO41903	UCEC	ICGC	VTPDGE	DEG_SCF_FBW7_2	0.712
p.Q628H	ACH-000467	Colon/Colorectal Cancer	CCLE	VTPDGE	DEG_SCF_FBW7_2	0.3056
p.Q628H	HCC-56	large_intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.3056
p.P640S	EN	endometrium	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.1667
p.P628S	EN	endometrium	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.3056
p.E638D	NCI-H1623	lung	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.2222
p.R642H	SNU-1040	large_intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.1111
p.R641H	SNU-1040	large_intestine	COSMIC	VTPDGE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12959	Disks large homolog 1	DEG_SCF_FBW7_2	629:634	VTPDGE	FBXW7	0.7714	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons