DegronMD

Uniprot ID: Q92796

Source protein: Disks large homolog 3

Source gene: DLG3

Class: LIG_APCC_ABBA_1

Location: 549:554

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9446

ASA_SCORE: 77.4667

COIL: 0.7682

CONS_SCORE: 0.5713

DSS_SCORE: 0.3498

HELIX: 0.0168

FCONS_SCORE: 0.9122

RIG_SCORE: 0.7311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P562H	TCGA-BF-A1Q0	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.1111
p.P562H	TCGA-CR-5248	HNSC	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.1111
p.D541E	TCGA-BF-AAP2	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.1111
p.G553R	TCGA-D1-A15X	UCEC	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.6457
p.G553R	TCGA-FI-A2D5	UCEC	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.6457
p.G553R	SIDM01175	Other Sarcomas	GDSC	VTPHGE	LIG_APCC_ABBA_1	0.6457
p.G553R	SW684	soft_tissue	COSMIC	VTPHGE	LIG_APCC_ABBA_1	0.6457
p.S539Y	TCGA-EE-A2GJ	SKCM	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.0556
p.T550S	TCGA-YA-A8S7	LIHC	TCGA	VTPHGE	LIG_APCC_ABBA_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92796	Disks large homolog 3	LIG_APCC_ABBA_1	549:554	VTPHGE	APC,CDC20,FZR1	0.9446	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons