DegronMD - Q8N196(SIX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P460L	TCGA-AP-A0LM	UCEC	TCGA	PPGY	ITCH	459:462	Mutation altering degron motif	0.7582
p.P460L	DO43306	UCEC	ICGC	PPGY	ITCH	459:462	Mutation altering degron motif	0.7582
p.T628S	TCGA-B5-A11E	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6005
p.T628S	DO41644	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.6005
p.S633N	TCGA-D1-A103	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.25
p.S633N	DO42312	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.25
p.A416V	TCGA-G4-6586	COAD	TCGA	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.1389
p.A416V	DO9698	COAD	ICGC	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.1389
p.G431A	TCGA-NH-A5IV	COAD	TCGA	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation altering degron motif	0.6429
p.G431A	DO49095	COAD	ICGC	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation altering degron motif	0.6429
p.P468L	DO230326	COCA	ICGC	PPGY	ITCH	459:462	Mutation rewiring degron network	0.1667
p.P635S	DO227999	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO229010	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO229013	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO229016	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO229003	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO229005	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.P635S	DO234285	ESAD	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1944
p.E419D	DO234462	ESAD	ICGC	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.2222
p.T434M	DO233671	GACA	ICGC	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.25
p.T616I	DO220890	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.0556
p.P460R	DO229253	THCA	ICGC	PPGY	ITCH	459:462	Mutation altering degron motif	0.7512
p.P413S	SIDM00263	Ewing's Sarcoma	GDSC	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.0556
p.P432S	ACH-000865	Esophageal Cancer	CCLE	GPLAQVVPG	DEG_SIAH_1	423:431	Mutation rewiring degron network	0.3056

Kaplan plot for SIX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIX5

UniProt ID: Q8N196

Entrez ID: 147912

Protein name: Homeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIX5 in