DegronMD

Uniprot ID: Q8N196

Source protein: Homeobox protein SIX5

Source gene: SIX5

Class: DEG_SPOP_SBC_1

Location: 626:630

E3 ligase: SPOP

DEGRON score: 0.921

ASA_SCORE: 76.86

COIL: 0.8866

CONS_SCORE: 0.357

DSS_SCORE: 0.6968

HELIX: 0.0658

FCONS_SCORE: 0.8638

RIG_SCORE: 0.5863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T628S	TCGA-B5-A11E	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	0.6005
p.T628S	DO41644	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	0.6005
p.S633N	TCGA-D1-A103	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	0.25
p.S633N	DO42312	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	0.25
p.P635S	DO227999	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO229010	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO229013	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO229016	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO229003	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO229005	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.P635S	DO234285	ESAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.T616I	DO220890	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	DEG_SPOP_SBC_1	17:21	AATTS	SPOP	0.9306	More...
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SPOP_SBC_1	86:90	AATTS	SPOP	0.9159	More...
P10244	Myb-related protein B	DEG_SPOP_SBC_1	247:251	AATTS	SPOP	0.875	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	191:195	AATTS	SPOP	0.8235	More...
P42345	Serine/threonine-protein kinase mTOR	DEG_SPOP_SBC_1	12:16	AATTS	SPOP	0.9477	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2479:2483	AATTS	SPOP	0.779	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3087:3091	AATTS	SPOP	0.9865	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4268:4272	AATTS	SPOP	0.5679	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	527:531	AATTS	SPOP	0.9908	More...
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	966:970	AATTS	SPOP	0.9712	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	745:749	AATTS	SPOP	0.8202	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6971:6975	AATTS	SPOP	0.943	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7089:7093	AATTS	SPOP	0.981	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7590:7594	AATTS	SPOP	0.9515	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7702:7706	AATTS	SPOP	0.987	More...
Q86W56	Poly	DEG_SPOP_SBC_1	18:22	AATTS	SPOP	0.9919	More...
Q8N196	Homeobox protein SIX5	DEG_SPOP_SBC_1	626:630	AATTS	SPOP	0.921	More...
Q8N1N2	Dynactin-associated protein	DEG_SPOP_SBC_1	194:198	AATTS	SPOP	0.9824	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	1118:1122	AATTS	SPOP	0.9724	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	292:296	AATTS	SPOP	0.9588	More...
Q9BWQ6	Protein YIPF2	DEG_SPOP_SBC_1	25:29	AATTS	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3496:3500	AATTS	SPOP	0.9359	More...
Q9NR56	Muscleblind-like protein 1	DEG_SPOP_SBC_1	352:356	AATTS	SPOP	0.9067	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	65:69	AATTS	SPOP	0.9829	More...
Q9P270	SLAIN motif-containing protein 2	DEG_SPOP_SBC_1	294:298	AATTS	SPOP	0.9583	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	148:152	AATTS	SPOP	0.9574	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	200:204	AATTS	SPOP	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTS

Degron related mutations and impact score

Drug responses associated with SIX5 mutations

All proteins holding degron of AATTS