DegronMD

Uniprot ID: Q16665

Source protein: Hypoxia-inducible factor 1-alpha

Source gene: HIF1A

Class: DEG_SPOP_SBC_1

Location: 745:749

E3 ligase: SPOP

DEGRON score: 0.8202

ASA_SCORE: 64.6

COIL: 0.7166

CONS_SCORE: 0.6937

DSS_SCORE: 0.4158

HELIX: 0.2386

FCONS_SCORE: 0.9731

RIG_SCORE: 0.7527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K745N	TCGA-B5-A11E	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	0.6918
p.G750D	TCGA-EY-A1GQ	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	0.3056
p.G750D	SIDM00526	Chronic Myelogenous Leukemia	GDSC	AATTS	DEG_SPOP_SBC_1	0.3056
p.G750D	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	AATTS	DEG_SPOP_SBC_1	0.3056
p.P746A	DO5207	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.7503
p.K743Q	DO223417	CLLE	ICGC	AATTS	DEG_SPOP_SBC_1	0.2778
p.A755V	DO229050	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1667
p.I747V	DO26842	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	0.7076
p.L736P	DO38599	STAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.0833
p.L736P	TOV-21G	ovary	COSMIC	AATTS	DEG_SPOP_SBC_1	0.0833
p.H745R	ACH-000914	Lymphoma	CCLE	AATTS	DEG_SPOP_SBC_1	0.8244
p.H745R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AATTS	DEG_SPOP_SBC_1	0.8244
p.R755C	ACH-000984	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	0.1667
p.R755H	ACH-000996	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	0.1667
p.K759T	23132-87	stomach	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1667
p.H744R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	AATTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	DEG_SPOP_SBC_1	17:21	AATTS	SPOP	0.9306	More...
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SPOP_SBC_1	86:90	AATTS	SPOP	0.9159	More...
P10244	Myb-related protein B	DEG_SPOP_SBC_1	247:251	AATTS	SPOP	0.875	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	191:195	AATTS	SPOP	0.8235	More...
P42345	Serine/threonine-protein kinase mTOR	DEG_SPOP_SBC_1	12:16	AATTS	SPOP	0.9477	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2479:2483	AATTS	SPOP	0.779	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3087:3091	AATTS	SPOP	0.9865	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4268:4272	AATTS	SPOP	0.5679	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	527:531	AATTS	SPOP	0.9908	More...
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	966:970	AATTS	SPOP	0.9712	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	745:749	AATTS	SPOP	0.8202	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6971:6975	AATTS	SPOP	0.943	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7089:7093	AATTS	SPOP	0.981	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7590:7594	AATTS	SPOP	0.9515	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7702:7706	AATTS	SPOP	0.987	More...
Q86W56	Poly	DEG_SPOP_SBC_1	18:22	AATTS	SPOP	0.9919	More...
Q8N196	Homeobox protein SIX5	DEG_SPOP_SBC_1	626:630	AATTS	SPOP	0.921	More...
Q8N1N2	Dynactin-associated protein	DEG_SPOP_SBC_1	194:198	AATTS	SPOP	0.9824	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	1118:1122	AATTS	SPOP	0.9724	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	292:296	AATTS	SPOP	0.9588	More...
Q9BWQ6	Protein YIPF2	DEG_SPOP_SBC_1	25:29	AATTS	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3496:3500	AATTS	SPOP	0.9359	More...
Q9NR56	Muscleblind-like protein 1	DEG_SPOP_SBC_1	352:356	AATTS	SPOP	0.9067	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	65:69	AATTS	SPOP	0.9829	More...
Q9P270	SLAIN motif-containing protein 2	DEG_SPOP_SBC_1	294:298	AATTS	SPOP	0.9583	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	148:152	AATTS	SPOP	0.9574	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	200:204	AATTS	SPOP	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTS

Degron related mutations and impact score

Drug responses associated with HIF1A mutations

All proteins holding degron of AATTS