DegronMD

Uniprot ID: Q9P270

Source protein: SLAIN motif-containing protein 2

Source gene: SLAIN2

Class: DEG_SPOP_SBC_1

Location: 294:298

E3 ligase: SPOP

DEGRON score: 0.9583

ASA_SCORE: 76.34

COIL: 0.6416

CONS_SCORE: 0.8793

DSS_SCORE: 0.568

HELIX: 0.3486

FCONS_SCORE: 0.9801

RIG_SCORE: 0.7091

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294L	DO35118	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	0.8428
p.R294C	DO233210	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	0.8301
p.R294H	DO51529	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	0.8244
p.R294H	DMS-79	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	0.8244
p.A297S	DO229031	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.7588
p.P296A	DO228585	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.7503
p.F293L	DO223588	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.75
p.V308G	DO222798	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.5
p.R299W	TCGA-29-1711	OV	TCGA	AATTS	DEG_SPOP_SBC_1	0.3056
p.R299W	ACH-000941	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	0.3056
p.R299L	TCGA-43-3920	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	0.3056
p.P299S	DO27429	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	0.3056
p.R300H	TCGA-AX-A06F	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	0.2778
p.P290L	DO219503	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	0.2222
p.A303S	DO229026	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.A303S	DO229038	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.S304L	TCGA-34-8454	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	0.1667
p.R305W	DO514	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1389
p.R305W	DO42600	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	0.1389
p.R305L	DO229038	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1389
p.R305Q	NCI-H1648	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 21 of 21 entries

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Drug responses associated with SLAIN2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AATTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	527:531	AATTS	SPOP	0.9908	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	148:152	AATTS	SPOP	0.9574	More...
Q8N1N2	Dynactin-associated protein	DEG_SPOP_SBC_1	194:198	AATTS	SPOP	0.9824	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	191:195	AATTS	SPOP	0.8235	More...
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SPOP_SBC_1	86:90	AATTS	SPOP	0.9159	More...
Q8N196	Homeobox protein SIX5	DEG_SPOP_SBC_1	626:630	AATTS	SPOP	0.921	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	745:749	AATTS	SPOP	0.8202	More...
O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	DEG_SPOP_SBC_1	17:21	AATTS	SPOP	0.9306	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6971:6975	AATTS	SPOP	0.943	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7089:7093	AATTS	SPOP	0.981	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7590:7594	AATTS	SPOP	0.9515	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7702:7706	AATTS	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2479:2483	AATTS	SPOP	0.779	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3087:3091	AATTS	SPOP	0.9865	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4268:4272	AATTS	SPOP	0.5679	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3496:3500	AATTS	SPOP	0.9359	More...
Q9NR56	Muscleblind-like protein 1	DEG_SPOP_SBC_1	352:356	AATTS	SPOP	0.9067	More...
P10244	Myb-related protein B	DEG_SPOP_SBC_1	247:251	AATTS	SPOP	0.875	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	65:69	AATTS	SPOP	0.9829	More...
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	966:970	AATTS	SPOP	0.9712	More...
Q86W56	Poly	DEG_SPOP_SBC_1	18:22	AATTS	SPOP	0.9919	More...
Q9BWQ6	Protein YIPF2	DEG_SPOP_SBC_1	25:29	AATTS	SPOP	0.9948	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	1118:1122	AATTS	SPOP	0.9724	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	292:296	AATTS	SPOP	0.9588	More...
P42345	Serine/threonine-protein kinase mTOR	DEG_SPOP_SBC_1	12:16	AATTS	SPOP	0.9477	More...

Showing 1 to 25 of 27 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTS

Degron related mutations and impact score

Drug responses associated with SLAIN2 mutations

All proteins holding degron of AATTS