DegronMD - O95263(PDE8B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I393S	TCGA-3B-A9I0	SARC	TCGA	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.25
p.R94S	TCGA-55-8203	LUAD	TCGA	AATTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.R94S	DO218928	LUAD	ICGC	AATTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.N387S	TCGA-86-8669	LUAD	TCGA	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.0833
p.R409S	TCGA-IB-7651	PAAD	TCGA	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1111
p.S401Y	TCGA-L5-A4OW	ESCA	TCGA	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation altering degron motif	0.712
p.V400A	DO227844	COCA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation altering degron motif	0.6936
p.S79N	DO222755	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	86:90	Mutation blocking phosphorylation signal	0.5833
p.S76I	DO233733	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.R394K	DO219685	KIRP	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.2778
p.R394K	MC116	haematopoietic and lymphoid tissue	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.2778
p.D399E	DO228890	LICA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation altering degron motif	0.5647
p.V400L	DO229028	LICA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation altering degron motif	0.6765
p.N392D	DO50842	LIRI	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation blocking ubiquitination signal	0.6667
p.R389S	DO46657	PAAD	ICGC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1389
p.R395C	SIDM01619	Endometrial Carcinoma	GDSC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.3056
p.R395C	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.3056
p.S99N	ACH-001956	Bone Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.R406Q	MCF7	breast	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1944
p.S402L	5637	urinary tract	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.3056
p.M394T	GP5d	large intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.2778
p.D87N	SK-MEL-3	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.6932
p.R390H	HCT-116	large intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1667
p.R390H	SNU-1040	large intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1667
p.A395V	SNU-1040	large intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.3056
p.S76A	NCI-H1688	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.E403K	CW-2	large intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.2778
p.Y391C	NCI-H2196	lung	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	396:401	Mutation rewiring degron network	0.1944

Kaplan plot for PDE8B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE8B

UniProt ID: O95263

Entrez ID: 8622

Protein name: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE8B in