DegronMD

Uniprot ID: O95263

Source protein: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Source gene: PDE8B

Class: DEG_SCF_TRCP1_1

Location: 396:401

E3 ligase: BTRC

DEGRON score: 0.9782

ASA_SCORE: 79.1

COIL: 0.839

CONS_SCORE: 0.2981

DSS_SCORE: 0.6286

HELIX: 0.0782

FCONS_SCORE: 1.033

RIG_SCORE: 0.5972

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I393S	TCGA-3B-A9I0	SARC	TCGA	DSGDNS	DEG_SCF_TRCP1_1	0.25
p.N387S	TCGA-86-8669	LUAD	TCGA	DSGDNS	DEG_SCF_TRCP1_1	0.0833
p.R409S	TCGA-IB-7651	PAAD	TCGA	DSGDNS	DEG_SCF_TRCP1_1	0.1111
p.S401Y	TCGA-L5-A4OW	ESCA	TCGA	DSGDNS	DEG_SCF_TRCP1_1	0.712
p.V400A	DO227844	COCA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.6936
p.R394K	DO219685	KIRP	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.2778
p.R394K	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.2778
p.D399E	DO228890	LICA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.5647
p.V400L	DO229028	LICA	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.6765
p.N392D	DO50842	LIRI	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.6667
p.R389S	DO46657	PAAD	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.1389
p.R395C	SIDM01619	Endometrial Carcinoma	GDSC	DSGDNS	DEG_SCF_TRCP1_1	0.3056
p.R395C	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGDNS	DEG_SCF_TRCP1_1	0.3056
p.R406Q	MCF7	breast	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.1944
p.S402L	5637	urinary_tract	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.3056
p.M394T	GP5d	large_intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.2778
p.R390H	HCT-116	large_intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.1667
p.R390H	SNU-1040	large_intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.1667
p.A395V	SNU-1040	large_intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.3056
p.E403K	CW-2	large_intestine	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.2778
p.Y391C	NCI-H2196	lung	COSMIC	DSGDNS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SCF_TRCP1_1	396:401	DSGDNS	BTRC	0.9782	More...
Q8IXQ3	Uncharacterized protein C9orf40	DEG_SCF_TRCP1_1	75:80	DSGDNS	BTRC	0.9539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons