DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C9orf40
UniProt ID:
Q8IXQ3
Entrez ID:
55071
Protein name:
Uncharacterized protein C9orf40
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
C9orf40
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S67W
TCGA-CV-A6JM
HNSC
TCGA
DSGDNS
DEG_SCF_TRCP1_1
75:80
Mutation blocking phosphorylation signal
0.5556
p.S67W
DO49991
HNSC
ICGC
DSGDNS
DEG_SCF_TRCP1_1
75:80
Mutation blocking phosphorylation signal
0.5556
p.P66T
DO25189
LUAD
ICGC
DSGDNS
DEG_SCF_TRCP1_1
75:80
Mutation rewiring degron network
0.0833
p.E88D
ACH-000592
Brain Cancer
CCLE
DSGDNS
DEG_SCF_TRCP1_1
75:80
Mutation rewiring degron network
0.1111
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C9orf40 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc