DegronMD

Uniprot ID: Q8IXQ3

Source protein: Uncharacterized protein C9orf40

Source gene: C9orf40

Class: DEG_SCF_TRCP1_1

Location: 75:80

E3 ligase: BTRC

DEGRON score: 0.9539

ASA_SCORE: 83.7167

COIL: 0.9265

CONS_SCORE: 0.5025

DSS_SCORE: 0.8997

HELIX: 0.0555

FCONS_SCORE: 0.8687

RIG_SCORE: 0.4609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S67W	TCGA-CV-A6JM	HNSC	TCGA	DSGDNS	DEG_SCF_TRCP1_1	0.5556
p.S67W	DO49991	HNSC	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.5556
p.P66T	DO25189	LUAD	ICGC	DSGDNS	DEG_SCF_TRCP1_1	0.0833
p.E88D	ACH-000592	Brain Cancer	CCLE	DSGDNS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SCF_TRCP1_1	396:401	DSGDNS	BTRC	0.9782	More...
Q8IXQ3	Uncharacterized protein C9orf40	DEG_SCF_TRCP1_1	75:80	DSGDNS	BTRC	0.9539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons