DegronMD - Q9P270(SLAIN2)

FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {ECO:0000269|PubMed:21646404}.

GO - Biological processes (BP): cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]

GO - Molecular function (MF):

GO - Cellular component (CC): centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LRRSLPNLS	DEG_APCC_DBOX_1	APC,CDC20,FZR1	SLAIN motif-containing protein 2	410:418	More..
AATTS	DEG_SPOP_SBC_1	SPOP	SLAIN motif-containing protein 2	294:298	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R294L	DO35118	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8428
p.R294C	DO233210	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8301
p.R294H	DO51529	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8244
p.R294H	DMS-79	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8244
p.A297S	DO229031	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7588
p.P296A	DO228585	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7503
p.F293L	DO223588	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.75
p.Y414H	DO41644	UCEC	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7229
p.R412C	TCGA-A5-A0G2	UCEC	TCGA	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.719
p.R412H	SIDM01619	Endometrial Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7133
p.R412H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7133
p.C413F	DO229041	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7108
p.S418P	SIDM02015	Colorectal Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.5641
p.V308G	DO222798	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.5
p.R299W	TCGA-29-1711	OV	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R299W	ACH-000941	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R299L	TCGA-43-3920	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P299S	DO27429	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R300H	TCGA-AX-A06F	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2778
p.S408R	DO222946	BTCA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.2778

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLAIN2

UniProt ID: Q9P270

Entrez ID: 57606

Protein name: SLAIN motif-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLAIN2 in