DegronMD - Q9P270(SLAIN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S402N	TCGA-06-5416	GBM	TCGA	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.R299W	TCGA-29-1711	OV	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R299W	ACH-000941	Endometrial/Uterine Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.S304L	TCGA-34-8454	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.R299L	TCGA-43-3920	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R412C	TCGA-A5-A0G2	UCEC	TCGA	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.719
p.R300H	TCGA-AX-A06F	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2778
p.F293L	DO223588	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.75
p.R305W	DO514	BLCA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.R305W	DO42600	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.S408R	DO222946	BTCA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.2778
p.V308G	DO222798	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.5
p.D407G	DO228581	GACA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.25
p.R294C	DO233210	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8301
p.P296A	DO228585	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7503
p.M404I	DO228933	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1667
p.M404I	DO229041	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1667
p.A303S	DO229026	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.A303S	DO229038	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.S408I	DO229026	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.2778
p.A297S	DO229031	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7588
p.R305L	DO229038	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.C413F	DO229041	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7108
p.P299S	DO27429	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.R294L	DO35118	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8428
p.R294H	DO51529	PACA	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8244
p.R294H	DMS-79	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.8244
p.D407Y	DO37643	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.25
p.G402C	DO37866	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.G402C	DO37444	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.P290L	DO219503	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.Y414H	DO41644	UCEC	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7229
p.S418P	SIDM02015	Colorectal Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.5641
p.S402R	SIDM00396	Acute Myeloid Leukemia	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.S402R	ACH-000112	Leukemia	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.S402R	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1111
p.T423I	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1944
p.T423I	ACH-000894	Lung Cancer	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1944
p.T423I	NCI-H1869	lung	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.1944
p.R412H	SIDM01619	Endometrial Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7133
p.R412H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation altering degron motif	0.7133
p.R305Q	NCI-H1648	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.Y401C	TT2609-C02	thyroid	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	410:418	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLAIN2

UniProt ID: Q9P270

Entrez ID: 57606

Protein name: SLAIN motif-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLAIN2 in