DegronMD

Uniprot ID: Q9P270

Source protein: SLAIN motif-containing protein 2

Source gene: SLAIN2

Class: DEG_APCC_DBOX_1

Location: 410:418

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 96.6778

COIL: 0.7519

CONS_SCORE: 0.9106

DSS_SCORE: 0.6395

HELIX: 0.2273

FCONS_SCORE: 1.3212

RIG_SCORE: 0.6951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S402N	TCGA-06-5416	GBM	TCGA	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.R412C	TCGA-A5-A0G2	UCEC	TCGA	LRRSLPNLS	DEG_APCC_DBOX_1	0.719
p.S408R	DO222946	BTCA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.2778
p.D407G	DO228581	GACA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.25
p.M404I	DO228933	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1667
p.M404I	DO229041	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1667
p.S408I	DO229026	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.2778
p.C413F	DO229041	LICA	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.7108
p.D407Y	DO37643	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.25
p.G402C	DO37866	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.G402C	DO37444	SKCM	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.Y414H	DO41644	UCEC	ICGC	LRRSLPNLS	DEG_APCC_DBOX_1	0.7229
p.S418P	SIDM02015	Colorectal Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	0.5641
p.S402R	SIDM00396	Acute Myeloid Leukemia	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.S402R	ACH-000112	Leukemia	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.S402R	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1111
p.T423I	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1944
p.T423I	ACH-000894	Lung Cancer	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	0.1944
p.T423I	NCI-H1869	lung	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	0.1944
p.R412H	SIDM01619	Endometrial Carcinoma	GDSC	LRRSLPNLS	DEG_APCC_DBOX_1	0.7133
p.R412H	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRRSLPNLS	DEG_APCC_DBOX_1	0.7133
p.Y401C	TT2609-C02	thyroid	COSMIC	LRRSLPNLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P270	SLAIN motif-containing protein 2	DEG_APCC_DBOX_1	410:418	LRRSLPNLS	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons