DegronMD

Uniprot ID: P42345

Source protein: Serine/threonine-protein kinase mTOR

Source gene: MTOR

Class: DEG_SPOP_SBC_1

Location: 12:16

E3 ligase: SPOP

DEGRON score: 0.9477

ASA_SCORE: 82.44

COIL: 0.85

CONS_SCORE: 0.2287

DSS_SCORE: 0.3891

HELIX: 0.1298

FCONS_SCORE: 0.9419

RIG_SCORE: 0.7266

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16H	QGP-1	pancreas	COSMIC	AATTS	DEG_SPOP_SBC_1	0.8244
p.N18S	DO234230	ESAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.2778
p.A9T	TCGA-A8-A08S	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	0.25
p.A9T	DO3140	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.25
p.A8S	TCGA-64-5779	LUAD	TCGA	AATTS	DEG_SPOP_SBC_1	0.2222
p.A8S	DO24930	LUAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.2222
p.S20R	DO229019	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.2222
p.V21I	TCGA-A6-6781	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	0.1944
p.V21I	DO8447	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.G3E	DO223142	ESCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.V6G	NCI-H522	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1667
p.G5R	TCGA-AK-3429	KIRC	TCGA	AATTS	DEG_SPOP_SBC_1	0.1389
p.G5R	DO17273	KIRC	ICGC	AATTS	DEG_SPOP_SBC_1	0.1389
p.E4K	Hs683	central_nervous_system	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 14 of 14 entries

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Drug responses associated with MTOR mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	JW-7-52-1	0.0068
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Voxtalisib	46.3581
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Temsirolimus	0.0112
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	JW-7-52-1	0.0731
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Voxtalisib	29.7542
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Temsirolimus	0.0128
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	JW-7-52-1	0.0372
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Voxtalisib	42.8346
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Temsirolimus	0.0089
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	QL-VIII-58	0.05
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.C1483Y (No)	GDSC	Temsirolimus	0.0031
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R2430M (No)	GDSC	Temsirolimus	0.0031
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	JW-7-52-1	0.084
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Voxtalisib	35.8215
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Temsirolimus	0.1032
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	JW-7-52-1	10.6824
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Voxtalisib	22.3813
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Temsirolimus	0.0055
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	JW-7-52-1	0.1344
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Voxtalisib	122.0187
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Temsirolimus	0.211
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	QL-VIII-58	0.1306
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Voxtalisib	134.1279
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Temsirolimus	0.0211
SIDM00562	BRCA\|breast	p.E427D (No)	GDSC	Voxtalisib	21.4042

Showing 1 to 25 of 310 entries

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All proteins holding degron of AATTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	527:531	AATTS	SPOP	0.9908	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	148:152	AATTS	SPOP	0.9574	More...
Q8N1N2	Dynactin-associated protein	DEG_SPOP_SBC_1	194:198	AATTS	SPOP	0.9824	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	191:195	AATTS	SPOP	0.8235	More...
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SPOP_SBC_1	86:90	AATTS	SPOP	0.9159	More...
Q8N196	Homeobox protein SIX5	DEG_SPOP_SBC_1	626:630	AATTS	SPOP	0.921	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	745:749	AATTS	SPOP	0.8202	More...
O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	DEG_SPOP_SBC_1	17:21	AATTS	SPOP	0.9306	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6971:6975	AATTS	SPOP	0.943	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7089:7093	AATTS	SPOP	0.981	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7590:7594	AATTS	SPOP	0.9515	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7702:7706	AATTS	SPOP	0.987	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2479:2483	AATTS	SPOP	0.779	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3087:3091	AATTS	SPOP	0.9865	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4268:4272	AATTS	SPOP	0.5679	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3496:3500	AATTS	SPOP	0.9359	More...
Q9NR56	Muscleblind-like protein 1	DEG_SPOP_SBC_1	352:356	AATTS	SPOP	0.9067	More...
P10244	Myb-related protein B	DEG_SPOP_SBC_1	247:251	AATTS	SPOP	0.875	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	65:69	AATTS	SPOP	0.9829	More...
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	966:970	AATTS	SPOP	0.9712	More...
Q86W56	Poly	DEG_SPOP_SBC_1	18:22	AATTS	SPOP	0.9919	More...
Q9BWQ6	Protein YIPF2	DEG_SPOP_SBC_1	25:29	AATTS	SPOP	0.9948	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	1118:1122	AATTS	SPOP	0.9724	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	292:296	AATTS	SPOP	0.9588	More...
P42345	Serine/threonine-protein kinase mTOR	DEG_SPOP_SBC_1	12:16	AATTS	SPOP	0.9477	More...

Showing 1 to 25 of 27 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTS

Degron related mutations and impact score

Drug responses associated with MTOR mutations

All proteins holding degron of AATTS