DegronMD

Uniprot ID: P42345

Source protein: Serine/threonine-protein kinase mTOR

Source gene: MTOR

Class: DEG_SPOP_SBC_1

Location: 12:16

E3 ligase: SPOP

DEGRON score: 0.9477

ASA_SCORE: 82.44

COIL: 0.85

CONS_SCORE: 0.2287

DSS_SCORE: 0.3891

HELIX: 0.1298

FCONS_SCORE: 0.9419

RIG_SCORE: 0.7266

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A8S	TCGA-64-5779	LUAD	TCGA	AATTS	DEG_SPOP_SBC_1	0.2222
p.A8S	DO24930	LUAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.2222
p.V21I	TCGA-A6-6781	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	0.1944
p.V21I	DO8447	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.A9T	TCGA-A8-A08S	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	0.25
p.A9T	DO3140	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.25
p.G5R	TCGA-AK-3429	KIRC	TCGA	AATTS	DEG_SPOP_SBC_1	0.1389
p.G5R	DO17273	KIRC	ICGC	AATTS	DEG_SPOP_SBC_1	0.1389
p.N18S	DO234230	ESAD	ICGC	AATTS	DEG_SPOP_SBC_1	0.2778
p.G3E	DO223142	ESCA	ICGC	AATTS	DEG_SPOP_SBC_1	0.1944
p.S20R	DO229019	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	0.2222
p.V6G	NCI-H522	lung	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1667
p.R16H	QGP-1	pancreas	COSMIC	AATTS	DEG_SPOP_SBC_1	0.8244
p.E4K	Hs683	central_nervous_system	COSMIC	AATTS	DEG_SPOP_SBC_1	0.1111

Drug responses associated with MTOR mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00901	UCEC\|endometrium	p.G803* (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.G803* (No)	GDSC	Temsirolimus	0.0311
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.Q188* (No)	GDSC	Temsirolimus	0.0888
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	Voxtalisib	219.2764
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	Temsirolimus	0.2884
SIDM00498	COREAD\|large_intestine	p.R1896* (No)	GDSC	QL-VIII-58	0.3386
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.C1483Y (No)	GDSC	Temsirolimus	0.0031
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	Voxtalisib	56.7962
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	Temsirolimus	0.1721
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.Q2072* (No)	GDSC	QL-VIII-58	0.1561
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	JW-7-52-1	0.107
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	Voxtalisib	18.5347
SIDM01206	NB\|neuroblastoma	p.F1888V (No)	GDSC	Temsirolimus	1.7238
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	JW-7-52-1	0.3796
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	Voxtalisib	72.4925
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	Temsirolimus	0.0633
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.S2215F (No)	GDSC	QL-VIII-58	0.1831
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	Temsirolimus	0.003
SIDM00333	UCEC\|endometrium	p.R766fs*24 (No)	GDSC	QL-VIII-58	0.0589
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.I2500M (No)	GDSC	QL-VIII-58	0.0483
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.R1161* (No)	GDSC	QL-VIII-58	0.0483
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	JW-7-52-1	0.0131
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	Voxtalisib	387.875
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	Temsirolimus	0.1309
SIDM00262	UNCLASSIFIED\|ewings_sarcoma	p.V1591L (No)	GDSC	QL-VIII-58	0.2248
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	Voxtalisib	10.1818
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	Temsirolimus	0.0209
SIDM00795	SKCM\|melanoma	p.R2152C (No)	GDSC	QL-VIII-58	0.2372
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	JW-7-52-1	0.2109
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	Voxtalisib	84.7699
SIDM00190	SKCM\|melanoma	p.M135T (No)	GDSC	Temsirolimus	0.4286
SIDM00572	STAD\|stomach	p.P1951S (No)	GDSC	Voxtalisib	212.5036
SIDM00572	STAD\|stomach	p.P1951S (No)	GDSC	Temsirolimus	0.0156
SIDM00826	COREAD\|large_intestine	p.P1193L (No)	GDSC	Voxtalisib	137.4487
SIDM00826	COREAD\|large_intestine	p.P1193L (No)	GDSC	Temsirolimus	0.398
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	Voxtalisib	137.4821
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	Temsirolimus	0.0788
SIDM00499	PRAD\|prostate	p.R1749Q (No)	GDSC	QL-VIII-58	0.0969
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	Voxtalisib	137.4821
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	Temsirolimus	0.0788
SIDM00499	PRAD\|prostate	p.V420I (No)	GDSC	QL-VIII-58	0.0969
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P1254T (No)	GDSC	QL-VIII-58	0.2462
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.M825I (No)	GDSC	QL-VIII-58	0.2462
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	JW-7-52-1	0.0436
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	Voxtalisib	20.4243
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	Temsirolimus	0.224
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.S275T (No)	GDSC	QL-VIII-58	0.2462
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	JW-7-52-1	0.0731
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Voxtalisib	29.7542
SIDM00145	ALL\|lymphoblastic_leukemia	p.A1134T (No)	GDSC	Temsirolimus	0.0128
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	Voxtalisib	68.7291
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	Temsirolimus	0.1081
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.A1134V (No)	GDSC	QL-VIII-58	0.2338
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	JW-7-52-1	0.0157
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	Voxtalisib	10.9668
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	Temsirolimus	0.2517
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.W1456R (No)	GDSC	QL-VIII-58	0.5448
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	JW-7-52-1	0.0827
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	Voxtalisib	58.3139
SIDM00661	DLBC\|B_cell_lymphoma	p.N1765D (No)	GDSC	Temsirolimus	0.0506
SIDM00901	UCEC\|endometrium	p.R1201Q (No)	GDSC	Voxtalisib	21.5643
SIDM00901	UCEC\|endometrium	p.R1201Q (No)	GDSC	Temsirolimus	0.0311
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	Voxtalisib	42.2335
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	Temsirolimus	0.0096
SIDM00334	UCEC\|endometrium	p.R1482C (No)	GDSC	QL-VIII-58	0.0735
SIDM00603	HNSC\|head_and_neck	p.A1134V (No)	GDSC	Voxtalisib	125.4869
SIDM00603	HNSC\|head_and_neck	p.A1134V (No)	GDSC	Temsirolimus	0.0807
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (No)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (No)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.F316fs*50 (No)	GDSC	QL-VIII-58	0.97
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	JW-7-52-1	0.039
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	Voxtalisib	263.7211
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	Temsirolimus	0.0253
SIDM00266	UNCLASSIFIED\|ewings_sarcoma	p.Q1207P (No)	GDSC	QL-VIII-58	0.0342
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	Voxtalisib	179.0272
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	Temsirolimus	0.1777
SIDM00098	MESO\|mesothelioma	p.L1037V (No)	GDSC	QL-VIII-58	0.409
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	Voxtalisib	179.0272
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	Temsirolimus	0.1777
SIDM00098	MESO\|mesothelioma	p.R260Q (No)	GDSC	QL-VIII-58	0.409
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.E2491D (No)	GDSC	QL-VIII-58	0.97
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	JW-7-52-1	0.2173
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	Voxtalisib	169.812
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	Temsirolimus	0.285
SIDM00781	COREAD\|large_intestine	p.R398C (No)	GDSC	QL-VIII-58	0.97
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	JW-7-52-1	0.0585
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	Voxtalisib	43.6877
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	Temsirolimus	0.0278
SIDM00142	UCEC\|endometrium	p.T2509A (No)	GDSC	QL-VIII-58	0.0638
SIDM00980	STAD\|stomach	p.H262R (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.H262R (No)	GDSC	Temsirolimus	0.0565
SIDM00980	STAD\|stomach	p.I261V (No)	GDSC	Voxtalisib	30.6098
SIDM00980	STAD\|stomach	p.I261V (No)	GDSC	Temsirolimus	0.0565
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	Voxtalisib	86.1679
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	Temsirolimus	0.0773
SIDM00666	LGG\|glioma	p.E1799K (No)	GDSC	QL-VIII-58	0.5659
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	Voxtalisib	98.9769
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	Temsirolimus	0.5448
SIDM00551	ESCA\|oesophagus	p.E2000Q (No)	GDSC	QL-VIII-58	1.4191
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	JW-7-52-1	0.0348
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	Voxtalisib	59.1462
SIDM00437	LAML\|acute_myeloid_leukaemia	p.T571K (No)	GDSC	Temsirolimus	0.0878
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	Voxtalisib	187.5287
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	Temsirolimus	0.3795
SIDM00711	SCLC\|lung_small_cell_carcinoma	p.F140L (No)	GDSC	QL-VIII-58	2.7109
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R2430M (No)	GDSC	Temsirolimus	0.0031
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	Voxtalisib	245.3216
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	Temsirolimus	1.11
SIDM00488	COREAD\|large_intestine	p.P1537S (No)	GDSC	QL-VIII-58	0.1352
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	JW-7-52-1	0.0217
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	Voxtalisib	31.6448
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P2466S (No)	GDSC	Temsirolimus	0.0039
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	Voxtalisib	21.6308
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	Temsirolimus	0.0735
SIDM00619	THCA\|thyroid	p.P1128L (No)	GDSC	QL-VIII-58	0.2299
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (Yes)	GDSC	JW-7-52-1	0.16
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (Yes)	GDSC	Voxtalisib	21.9483
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (Yes)	GDSC	Temsirolimus	0.2066
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.M1V (Yes)	GDSC	QL-VIII-58	0.0652
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	JW-7-52-1	0.16
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	Voxtalisib	21.9483
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	Temsirolimus	0.2066
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.F1545L (No)	GDSC	QL-VIII-58	0.0652
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	Voxtalisib	85.432
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	Temsirolimus	0.1675
SIDM01045	UCEC\|endometrium	p.Y861H (No)	GDSC	QL-VIII-58	1.2478
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	Voxtalisib	281.1758
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	Temsirolimus	0.0206
SIDM01028	ESCA\|oesophagus	p.R1709H (No)	GDSC	QL-VIII-58	0.1261
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	JW-7-52-1	0.1344
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Voxtalisib	122.0187
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	Temsirolimus	0.211
SIDM00946	ALL\|T_cell_leukemia	p.K550N (No)	GDSC	QL-VIII-58	0.1306
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	JW-7-52-1	0.1165
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	Voxtalisib	58.2367
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.P2490A (No)	GDSC	Temsirolimus	0.0776
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	Voxtalisib	51.8381
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	Temsirolimus	0.003
SIDM00333	UCEC\|endometrium	p.K1981E (No)	GDSC	QL-VIII-58	0.0589
SIDM01193	GBM\|glioma	p.L1129P (No)	GDSC	Voxtalisib	134.8685
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	JW-7-52-1	0.0068
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Voxtalisib	46.3581
SIDM01217	ALL\|leukemia	p.W1449_H1454delinsAL (No)	GDSC	Temsirolimus	0.0112
SIDM00217	COREAD\|large_intestine	p.R1208C (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.T1143M (No)	GDSC	Voxtalisib	169.1451
SIDM00217	COREAD\|large_intestine	p.S1087N (No)	GDSC	Voxtalisib	169.1451
SIDM00140	SKCM\|melanoma	p.P453L (No)	GDSC	Voxtalisib	130.0637
SIDM00140	SKCM\|melanoma	p.P453L (No)	GDSC	Temsirolimus	0.1542
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	Voxtalisib	1260.2281
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	Temsirolimus	0.5714
SIDM00466	OV\|ovary	p.T1834_T1837delTAAT (No)	GDSC	QL-VIII-58	2.2905
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	JW-7-52-1	0.1008
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	Voxtalisib	38.3355
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.G1491S (No)	GDSC	Temsirolimus	0.0541
SIDM00216	COREAD\|large_intestine	p.T588M (No)	GDSC	Voxtalisib	21.2501
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.L573F (No)	GDSC	Voxtalisib	43.6878
SIDM00552	UNCLASSIFIED\|rhabdomyosarcoma	p.L573F (No)	GDSC	Temsirolimus	0.0278
SIDM00231	KIRC\|kidney	p.L2209V (No)	GDSC	Temsirolimus	0.1737
SIDM00231	KIRC\|kidney	p.L2209V (No)	GDSC	QL-VIII-58	2.0362
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	JW-7-52-1	0.7719
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	Voxtalisib	14.8856
SIDM01198	UNCLASSIFIED\|Burkitt_lymphoma	p.L2427R (No)	GDSC	Temsirolimus	0.083
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.G2238D (No)	GDSC	QL-VIII-58	22.133
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.P1408S (No)	GDSC	QL-VIII-58	22.133
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	JW-7-52-1	12.9145
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	Voxtalisib	116.8252
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	Temsirolimus	4.6851
SIDM00282	COREAD\|large_intestine	p.M488I (No)	GDSC	QL-VIII-58	22.133
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	JW-7-52-1	0.0283
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	Voxtalisib	397.1146
SIDM00613	LGG\|glioma	p.R1208C (No)	GDSC	Temsirolimus	0.0667
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	JW-7-52-1	0.0843
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	Voxtalisib	131.4537
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	Temsirolimus	0.2944
SIDM00150	COREAD\|large_intestine	p.P1254L (No)	GDSC	QL-VIII-58	3.8198
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.V1801G (No)	GDSC	Voxtalisib	171.7416
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	Voxtalisib	149.8482
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	Temsirolimus	0.0656
SIDM00609	KIRC\|kidney	p.W1304R (No)	GDSC	QL-VIII-58	0.9736
SIDM01026	ESCA\|oesophagus	p.R1208C (No)	GDSC	Voxtalisib	93.4419
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	Voxtalisib	109.0545
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	Temsirolimus	1.5935
SIDM00534	COREAD\|large_intestine	p.A695V (No)	GDSC	QL-VIII-58	1.7963
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	JW-7-52-1	5.6514
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	Voxtalisib	64.7542
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	Temsirolimus	1.22
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P1609L (No)	GDSC	QL-VIII-58	0.885
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	Voxtalisib	34.8403
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	Temsirolimus	2.8221
SIDM00487	COREAD\|large_intestine	p.L342P (No)	GDSC	QL-VIII-58	1.7019
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	JW-7-52-1	0.0205
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	Voxtalisib	35.8859
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	Temsirolimus	0.0236
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312L (No)	GDSC	QL-VIII-58	0.1273
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	JW-7-52-1	0.0205
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	Voxtalisib	35.8859
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	Temsirolimus	0.0236
SIDM01161	UNCLASSIFIED\|soft_tissue_other	p.P1312S (No)	GDSC	QL-VIII-58	0.1273
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Voxtalisib	134.1279
SIDM00414	BLCA\|bladder	p.E1033K (No)	GDSC	Temsirolimus	0.0211
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	Voxtalisib	45.5299
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	Temsirolimus	0.058
SIDM00820	KIRC\|kidney	p.P770A (No)	GDSC	QL-VIII-58	1.4707
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	JW-7-52-1	0.7926
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	Voxtalisib	42.3339
SIDM00083	LGG\|glioma	p.M476V (No)	GDSC	Temsirolimus	0.0673
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.H1647Q (No)	GDSC	Voxtalisib	122.2226
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.H1647Q (No)	GDSC	Temsirolimus	0.2295
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.K1197N (No)	GDSC	Voxtalisib	72.3957
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.K1197N (No)	GDSC	Temsirolimus	0.2383
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	JW-7-52-1	0.7438
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	Voxtalisib	139.1593
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	Temsirolimus	0.1617
SIDM01233	COREAD\|large_intestine	p.Y1151C (No)	GDSC	QL-VIII-58	3.9052
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	JW-7-52-1	0.0097
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	Voxtalisib	75.1955
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	Temsirolimus	0.011
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.I2017T (No)	GDSC	QL-VIII-58	0.0686
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	Voxtalisib	192.582
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	Temsirolimus	0.2147
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.S645C (No)	GDSC	QL-VIII-58	0.1935
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	JW-7-52-1	0.084
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Voxtalisib	35.8215
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.S383G (No)	GDSC	Temsirolimus	0.1032
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	JW-7-52-1	12.0633
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	Voxtalisib	238.6089
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	Temsirolimus	0.2747
SIDM00779	COREAD\|large_intestine	p.L1666R (No)	GDSC	QL-VIII-58	2.1347
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	JW-7-52-1	1.8322
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	Voxtalisib	368.4887
SIDM00296	SCLC\|lung_small_cell_carcinoma	p.T2471M (No)	GDSC	Temsirolimus	0.1728
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	Voxtalisib	852.3455
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	Temsirolimus	0.4247
SIDM00360	UNCLASSIFIED\|pancreas	p.R1811H (No)	GDSC	QL-VIII-58	0.8073
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	JW-7-52-1	0.0254
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	Voxtalisib	12.5998
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.A41T (No)	GDSC	Temsirolimus	0.0368
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	Voxtalisib	168.3281
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	Temsirolimus	0.0814
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.D259Y (No)	GDSC	QL-VIII-58	0.2089
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	Voxtalisib	199.5219
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	Temsirolimus	0.0669
SIDM00890	SKCM\|melanoma	p.R1612Q (No)	GDSC	QL-VIII-58	0.7659
SIDM00444	ESCA\|oesophagus	p.D1332E (No)	GDSC	Voxtalisib	80.6232
SIDM00444	ESCA\|oesophagus	p.D1332E (No)	GDSC	Temsirolimus	1.0691
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	JW-7-52-1	0.7498
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	Voxtalisib	59.2226
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.T2232I (No)	GDSC	Temsirolimus	0.4096
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	Voxtalisib	44.3158
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	Temsirolimus	1.2607
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A1728S (No)	GDSC	QL-VIII-58	0.7118
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	Voxtalisib	44.3158
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	Temsirolimus	1.2607
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.A41P (No)	GDSC	QL-VIII-58	0.7118
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	JW-7-52-1	0.0372
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Voxtalisib	42.8346
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	Temsirolimus	0.0089
SIDM01259	ALL\|lymphoblastic_leukemia	p.A954T (No)	GDSC	QL-VIII-58	0.05
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	Voxtalisib	46.0663
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	Temsirolimus	0.7728
SIDM00537	COREAD\|large_intestine	p.T1948M (No)	GDSC	QL-VIII-58	0.4692
SIDM01146	STAD\|stomach	p.T431A (No)	GDSC	JW-7-52-1	0.3203
SIDM01146	STAD\|stomach	p.T431A (No)	GDSC	Voxtalisib	19.3856
SIDM00562	BRCA\|breast	p.E427D (No)	GDSC	Voxtalisib	21.4042
SIDM00562	BRCA\|breast	p.E427D (No)	GDSC	Temsirolimus	0.1894
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	Voxtalisib	273.5461
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	Temsirolimus	0.0026
SIDM00238	OV\|ovary	p.T647I (No)	GDSC	QL-VIII-58	0.1126
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	Temsirolimus	1.0967
SIDM00878	BRCA\|breast	p.Q2072R (No)	GDSC	QL-VIII-58	0.1555
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	Voxtalisib	105.6871
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	Temsirolimus	1.0967
SIDM00878	BRCA\|breast	p.H642R (No)	GDSC	QL-VIII-58	0.1555
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	JW-7-52-1	10.6824
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Voxtalisib	22.3813
SIDM00410	ALL\|lymphoid_neoplasm_other	p.P1408S (No)	GDSC	Temsirolimus	0.0055
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	Voxtalisib	69.0575
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	Temsirolimus	0.0023
SIDM00817	KIRC\|kidney	p.L2138F (No)	GDSC	QL-VIII-58	0.0586
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	Voxtalisib	56.6765
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	Temsirolimus	0.0143
SIDM00193	COREAD\|large_intestine	p.L1894V (No)	GDSC	QL-VIII-58	0.3664
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.C1497F (No)	GDSC	QL-VIII-58	0.0483
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	Voxtalisib	100.3516
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	Temsirolimus	1.1908
SIDM00118	COREAD\|large_intestine	p.R281C (No)	GDSC	QL-VIII-58	0.0483

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75427	Leucine-rich repeat and calponin homology domain-containing protein 4	DEG_SPOP_SBC_1	17:21	AATTS	SPOP	0.9306	More...
O95263	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	DEG_SPOP_SBC_1	86:90	AATTS	SPOP	0.9159	More...
P10244	Myb-related protein B	DEG_SPOP_SBC_1	247:251	AATTS	SPOP	0.875	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	191:195	AATTS	SPOP	0.8235	More...
P42345	Serine/threonine-protein kinase mTOR	DEG_SPOP_SBC_1	12:16	AATTS	SPOP	0.9477	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2479:2483	AATTS	SPOP	0.779	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3087:3091	AATTS	SPOP	0.9865	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4268:4272	AATTS	SPOP	0.5679	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	527:531	AATTS	SPOP	0.9908	More...
Q15596	Nuclear receptor coactivator 2	DEG_SPOP_SBC_1	966:970	AATTS	SPOP	0.9712	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	745:749	AATTS	SPOP	0.8202	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6971:6975	AATTS	SPOP	0.943	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7089:7093	AATTS	SPOP	0.981	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7590:7594	AATTS	SPOP	0.9515	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7702:7706	AATTS	SPOP	0.987	More...
Q86W56	Poly	DEG_SPOP_SBC_1	18:22	AATTS	SPOP	0.9919	More...
Q8N196	Homeobox protein SIX5	DEG_SPOP_SBC_1	626:630	AATTS	SPOP	0.921	More...
Q8N1N2	Dynactin-associated protein	DEG_SPOP_SBC_1	194:198	AATTS	SPOP	0.9824	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	1118:1122	AATTS	SPOP	0.9724	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	292:296	AATTS	SPOP	0.9588	More...
Q9BWQ6	Protein YIPF2	DEG_SPOP_SBC_1	25:29	AATTS	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3496:3500	AATTS	SPOP	0.9359	More...
Q9NR56	Muscleblind-like protein 1	DEG_SPOP_SBC_1	352:356	AATTS	SPOP	0.9067	More...
Q9NV92	NEDD4 family-interacting protein 2	DEG_SPOP_SBC_1	65:69	AATTS	SPOP	0.9829	More...
Q9P270	SLAIN motif-containing protein 2	DEG_SPOP_SBC_1	294:298	AATTS	SPOP	0.9583	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	148:152	AATTS	SPOP	0.9574	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	200:204	AATTS	SPOP	0.9314	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTS

Degron related mutations and impact score

Drug responses associated with MTOR mutations

All proteins holding degron of AATTS